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2019, Vol: 9, Issue: 1
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Review Article 


Thiazolidinediones and their Drug Interactions involving CYP enzymes

Naina Mohamed Pakkir Maideen.

Abstract
Background:
Thiazolidinediones (TZDs) include Pioglitazone and Rosiglitazone and they are indicated in the treatment of type 2 diabetes mellitus. They are insulin sensitizers and are metabolised primarily by CYP2C8 enzyme. The drugs inhibiting or inducing CYP2C8 enzyme may result in pharmacokinetic drug interactions of TZDs. The probability of drug interactions is higher in type 2 diabetic patients as they administer many medications to manage blood glucose and to treat other diseases. Clinically significant drug interactions of TZDs are discussed in this review.
Methods:
The literature review was done in databases like Medline/PubMed/PMC, Science Direct, Google scholar, Directory of open access journals (DOAJ), and reference lists to identify relevant articles.
Results:
The drugs inhibiting the CYP2C8 enzyme such as Gemfibrozil, Clopidogrel, Trimethoprim, Ketoconazole and Rifampicin have been identified to affect the pharmacokinetics of TZDs.
Conclusion:
The clinicians need to be aware of adverse drug interactions of TZDs to prevent negative outcomes.

Key words: Drug interactions; Thiazolidinedione antidiabetics; Pioglitazone; Rosiglitazone; CYP2C8; CYP2C9.


 
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Pubmed Style

Maideen NMP, . Thiazolidinediones and their Drug Interactions involving CYP enzymes . A J Physiol Biochem Pharmacol. 2018; 8(2): 47-54. doi:10.5455/ajpbp.20181022083057

Web Style

Maideen NMP, . Thiazolidinediones and their Drug Interactions involving CYP enzymes . http://www.ajpbp.com/?mno=12698 [Access: April 22, 2019]. doi:10.5455/ajpbp.20181022083057

AMA (American Medical Association) Style

Maideen NMP, . Thiazolidinediones and their Drug Interactions involving CYP enzymes . A J Physiol Biochem Pharmacol. 2018; 8(2): 47-54. doi:10.5455/ajpbp.20181022083057


Vancouver/ICMJE Style

Maideen NMP, . Thiazolidinediones and their Drug Interactions involving CYP enzymes . A J Physiol Biochem Pharmacol. (2018), [cited April 22, 2019]; 8(2): 47-54. doi:10.5455/ajpbp.20181022083057


Harvard Style

Maideen, N. M. . P. & (2018) Thiazolidinediones and their Drug Interactions involving CYP enzymes . A J Physiol Biochem Pharmacol, 8 (2), 47-54. doi:10.5455/ajpbp.20181022083057


Turabian Style

Maideen, Naina Mohamed Pakkir, and . 2018. Thiazolidinediones and their Drug Interactions involving CYP enzymes . American Journal of Physiology, Biochemistry and Pharmacology, 8 (2), 47-54. doi:10.5455/ajpbp.20181022083057


Chicago Style

Maideen, Naina Mohamed Pakkir, and . "Thiazolidinediones and their Drug Interactions involving CYP enzymes ." American Journal of Physiology, Biochemistry and Pharmacology 8 (2018), 47-54. doi:10.5455/ajpbp.20181022083057


MLA (The Modern Language Association) Style

Maideen, Naina Mohamed Pakkir, and . "Thiazolidinediones and their Drug Interactions involving CYP enzymes ." American Journal of Physiology, Biochemistry and Pharmacology 8.2 (2018), 47-54. Print. doi:10.5455/ajpbp.20181022083057


APA (American Psychological Association) Style

Maideen, N. M. . P. & (2018) Thiazolidinediones and their Drug Interactions involving CYP enzymes . American Journal of Physiology, Biochemistry and Pharmacology, 8 (2), 47-54. doi:10.5455/ajpbp.20181022083057




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