Thiazolidinediones and their Drug Interactions involving 
CYP enzymes

Naina Mohamed##Pakkir Maideen|

2019, Vol: 9, Issue: 1

9/1Current Issue Online First Archive Aims and Scope Abstracting & Indexing Most Accessed Articles Most Downloaded Articles Most Cited Articles

Required files to uploaded

« Previous Article

Review Article

A J Physiol Biochem Pharmacol. 2018; 8(2): 47-54

doi: 10.5455/ajpbp.20181022083057

Thiazolidinediones and their Drug Interactions involving CYP enzymes

Naina Mohamed Pakkir Maideen.

Abstract
Background:
Thiazolidinediones (TZDs) include Pioglitazone and Rosiglitazone and they are indicated in the treatment of type 2 diabetes mellitus. They are insulin sensitizers and are metabolised primarily by CYP2C8 enzyme. The drugs inhibiting or inducing CYP2C8 enzyme may result in pharmacokinetic drug interactions of TZDs. The probability of drug interactions is higher in type 2 diabetic patients as they administer many medications to manage blood glucose and to treat other diseases. Clinically significant drug interactions of TZDs are discussed in this review.
Methods:
The literature review was done in databases like Medline/PubMed/PMC, Science Direct, Google scholar, Directory of open access journals (DOAJ), and reference lists to identify relevant articles.
Results:
The drugs inhibiting the CYP2C8 enzyme such as Gemfibrozil, Clopidogrel, Trimethoprim, Ketoconazole and Rifampicin have been identified to affect the pharmacokinetics of TZDs.
Conclusion:
The clinicians need to be aware of adverse drug interactions of TZDs to prevent negative outcomes.

Key words: Drug interactions; Thiazolidinedione antidiabetics; Pioglitazone; Rosiglitazone; CYP2C8; CYP2C9.

	ARTICLE TOOLS
	Abstract
	PDF Fulltext
	Print this Article
	How to cite this article
	Citation Tools
	Related Records
	Articles by Naina Mohamed Pakkir Maideen
	on Google
	on Google Scholar
	Article Statistics
	Viewed: 743 Downloaded: Cited: 0

How to Cite this Article

Pubmed Style

Maideen NMP, . Thiazolidinediones and their Drug Interactions involving CYP enzymes . A J Physiol Biochem Pharmacol. 2018; 8(2): 47-54. doi:10.5455/ajpbp.20181022083057

Web Style

Maideen NMP, . Thiazolidinediones and their Drug Interactions involving CYP enzymes . http://www.ajpbp.com/?mno=12698 [Access: February 21, 2019]. doi:10.5455/ajpbp.20181022083057

AMA (American Medical Association) Style

Maideen NMP, . Thiazolidinediones and their Drug Interactions involving CYP enzymes . A J Physiol Biochem Pharmacol. 2018; 8(2): 47-54. doi:10.5455/ajpbp.20181022083057

Vancouver/ICMJE Style

Maideen NMP, . Thiazolidinediones and their Drug Interactions involving CYP enzymes . A J Physiol Biochem Pharmacol. (2018), [cited February 21, 2019]; 8(2): 47-54. doi:10.5455/ajpbp.20181022083057

Harvard Style

Maideen, N. M. . P. & (2018) Thiazolidinediones and their Drug Interactions involving CYP enzymes . A J Physiol Biochem Pharmacol, 8 (2), 47-54. doi:10.5455/ajpbp.20181022083057

Turabian Style

Maideen, Naina Mohamed Pakkir, and . 2018. Thiazolidinediones and their Drug Interactions involving CYP enzymes . American Journal of Physiology, Biochemistry and Pharmacology, 8 (2), 47-54. doi:10.5455/ajpbp.20181022083057

Chicago Style

Maideen, Naina Mohamed Pakkir, and . "Thiazolidinediones and their Drug Interactions involving CYP enzymes ." American Journal of Physiology, Biochemistry and Pharmacology 8 (2018), 47-54. doi:10.5455/ajpbp.20181022083057

MLA (The Modern Language Association) Style

APA (American Psychological Association) Style

Maideen, N. M. . P. & (2018) Thiazolidinediones and their Drug Interactions involving CYP enzymes . American Journal of Physiology, Biochemistry and Pharmacology, 8 (2), 47-54. doi:10.5455/ajpbp.20181022083057

Contact Information

Your comments are very important to us

How to cite this article

This is an open access journal which means that all content is freely available without charge to the user or his/her institution. Users are allowed to read, download, copy, distribute, print, search, or link to the full texts of the articles in this journal without asking prior permission from the publisher or the author. This is in accordance with the Budapest Open Access Initiative (BOAI) definition of open access. The articles in American Journal of Physiology, Biochemistry and Pharmacology are open access articles licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc-sa/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

Copyright © 2019 American Journal of Physiology, Biochemistry and Pharmacology All Rights Reserved. Subject to change without notice from or liability to American Journal of Physiology, Biochemistry and Pharmacology. For best results, please use Internet Explorer or Google Chrome	Contact Information Your comments are very important to us We welcome your ideas, suggestions, comments, or questions. To reach Editorial Board please use one of the methods provided below. Call us at (302) 355 0333. Our office hours are Monday - Friday, 8 AM to 5 PM EST. Or e-mail us at info@ejmanager.com We will respond within 48 to 72 hours. Change of address or personal information? Please visit your account at www.ejmanager.com to update your information.