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Myeloperoxidase, Malondialdehyde and serum Lipids in type 2 diabetes mellitus

Mohamedi Begum, Ashok Kumar J., Hilda Priya D'Souza, Sushith Sushith, Prathima M.B, Reshma S., Shashikala M.D, Manjula Anil, Suriyan S Nair, Kavitha Ashok Kumar.

Cited by (3)

Abstract
Introduction:
In diabetics, oxidative stress participates in all stages of cardiovascular disease, from lipoprotein modification to plaque rupture and biomarkers of oxidative stress enhances development of cardiovascular complications. AIP is related directly to the atherosclerotic risk.

Oxidative stress biomarkers merit investigation for the value they may offer for long-term cardiovascular risk prediction. . In view of above consideration, this study was taken to compare and correlate the levels of oxidative stress markers and AIP in type 2 diabetic patients.

Methods:
A total of 140 individuals of which 70 are type 2 diabetics and 70 are age and sex matched controls. Levels of serum MPO, MDA, TC, LDL, TG, HDL cholesterol and AIP is measured in these study population.
Results and conclusion:
Statistically significant increase in BMI (27.2 ±1.2 kgs/m²), WHR(1.02 ± 0.04 ), serum MPO (211.71 ± 2.24μmol/min) and MDA(549 ± 45 nanomoles/100ml), TC(274 ± 24 mg/dl), TG (189 ± 2.5mg/dl) , LDL(207 ±45mg/dl ) and AIP(0.47 ±0.02) was seen in type 2 diabetic patients when compared to controls. The levels of these parameters is higher in diabetics patients having diabetes≥10 yrs and serum cholesterol ≥200 mg/dl. AIP was positively correlated with the levels of serum MPO, MDA, TC, TG, LDL and negatively correlated with serum HDL cholesterol which was statistically significant.
By measuring serum MPO, MDA, lipid profile and AIP helps in long term cardiovascular risk assessment in patients with diabetes and by measuring these parameters help to detect these complications as early as possible and early interventions can be done to prevent future development of cardiovascular complications.

Key words: MPO, MDA, AIP, Type 2 Diabetes Mellitus, Oxidative stress


 
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REFERENCES
1. Amanullah S, Ja rari A, Govindan M, Basha MI, Khatheeja S. Association of hs-CRP with diabetic and non-diabetic individuals. Jordan J Biol Sci 2010;3:7-12.
2. Creager MA, Lusher TF, Cosentino F, Beckman JA. Diabetes and vascular disease. pathophysiology, clinical consequences, and medical therapy: Part I. J Am Heart Assoc 2003;108:1527-32. [DOI via Crossref]   
3. Heslop CL, Frohlich JJ, Hill JS. Myeloperoxidase and C-reactive protein have combined utility for long-term prediction of cardiovascular mortality after coronary angiography. J Am Coll Cardiol 2010;55:1102-9. [DOI via Crossref]    [Pubmed]   
4. Bhutia Y, Ghosh A, Sherpa ML, Pal R, Mohanta PK. Serum malondialdehyde level: Surrogate stress marker in the Sikkimese diabetics. J Nat Sci Biol Med 2011;2:107-12. [DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   
5. Anand AV, Muneeb M, Divya N, Senthil R, Kapoor MM, Gowri J, et al. Clinical significance of hypertension, diabetes and inflammation, as predictor of cardiovascular diseae. Int J Biol Med Res 2011;2:369-73.
6. Panteghini M, Bais R. Serum enzymes. In: Burtis CA, Ashwood ER, Bruns DE, editors. Tietz Textbook of Clinical Chemistry and Molecular Diagnostics. 5th ed. St. Louis: Saunders Elsevier; 2012. p. 594-5. [DOI via Crossref]   
7. Slatter DA, Bolton CH, Bailey AJ. The importance of lipid-derived malondialdehyde in diabetes mellitus. Diabetologia 2000;43:550-7. [DOI via Crossref]    [Pubmed]   
8. Calin P, Maria P. Atherogenic risk quantification by using the atherogenic index of plasma (AIP) and cardiovascular risk calculator on hypertensive patients. Med Connect 2013;1:29-36.
9. Cameron AJ, Magliano DJ, Shaw JE, Zimmet PZ, Carstensen B, Alberti KG, et al. The influence of hip circumference on the relationship between abdominal obesity and mortality. Int J Epidemiol 2012;41:484-94. [DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   
10. Allain CC, Poon LS, Chan CS, Richmond W, Fu PC. Enzymatic determination of total serum cholesterol. Clin Chem 1974;20:470-5. [Pubmed]   
11. Buccolo G, David M. Quantitative determination of serum triglycerides by the use of enzymes. Clin Chem 1973;19:476-82.
12. Assmann G. Estimation HDL cholesterol. Clin Chem 1979;20:559.50.
13. Bradley PP, Priebat DA, Christensen RD, Rothstein G. Measurement of cutaneous inflammation: Estimation of neutrophil content with an enzyme marker. J Invest Dermatol 1982;78:206-9. [DOI via Crossref]    [Pubmed]   
14. Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 1979;95:351-8. [DOI via Crossref]   
15. Tariq M. Comparative study for atherogenic index of plasma (AIP) in patients with type1 diabetes mellitus, type2 diabetes mellitus, betathalassemia, and hypothyroidism. Int J Chem Res 2012;v02i2:01-9.
16. Shetty JK, Prakash M, Ibrahim MS. Relationship between free iron and glycated hemoglobin in uncontrolled type 2 diabetes patients associated with complications. Indian J Clin Biochem 2008;23:67-70. [DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   
17. Suryawanshi NP, Bhutey AK, Nagdeote AN, Jadhav AA, Manoorkar GS. Study of lipid peroxide and lipid profile in diabetes mellitus. Indian J Clin Biochem 2006;21:126-30. [DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   
18. Sabzwari MJ, Ahmad M, Majeed MT, Riaz M, Umair M. Serum sialic acid concentration and type 2 diabetes mellitus. Prof Med J 2006;13:508-10.
19. Nayak BS, Roberts L. Relationship between inflammatory markers, metabolic and anthropometric variables in the Caribbean type 2 diabetic patients with and without microvascular complications. J Inflamm (Lond) 2006;3:17. [DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   
20. Abdel-Aal NM, Ahmad AT, Froelicher ES, Batieha AM, Hamza MM, Ajlouni KM. Prevalence of dyslipidemia in patients with type 2 diabetes in Jordan. Saudi Med J 2008;29:1423-8. [Pubmed]   
21. Fox CS, Sullivan L, D'Agostino RB Sr, Wilson PW, Framingham Heart Study. The significant effect of diabetes duration on coronary heart disease mortality: The Framingham Heart Study. Diabetes Care 2004;27:704-8. [DOI via Crossref]    [Pubmed]   

This Article Cited By the following articles

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How to Cite this Article
Pubmed Style

Mohamedi Begum, Ashok Kumar J., Hilda Priya DSouza, Sushith Sushith, Prathima M.B, Reshma S., Shashikala M.D, Manjula Anil, Suriyan S Nair, Kavitha Ashok Kumar. Myeloperoxidase, Malondialdehyde and serum Lipids in type 2 diabetes mellitus . A J Physiol Biochem Pharmacol. 2015; 4(1): 13-17. doi:10.5455/jib.20150331115356


Web Style

Mohamedi Begum, Ashok Kumar J., Hilda Priya DSouza, Sushith Sushith, Prathima M.B, Reshma S., Shashikala M.D, Manjula Anil, Suriyan S Nair, Kavitha Ashok Kumar. Myeloperoxidase, Malondialdehyde and serum Lipids in type 2 diabetes mellitus . http://www.ajpbp.com/?mno=151251 [Access: November 18, 2018]. doi:10.5455/jib.20150331115356


AMA (American Medical Association) Style

Mohamedi Begum, Ashok Kumar J., Hilda Priya DSouza, Sushith Sushith, Prathima M.B, Reshma S., Shashikala M.D, Manjula Anil, Suriyan S Nair, Kavitha Ashok Kumar. Myeloperoxidase, Malondialdehyde and serum Lipids in type 2 diabetes mellitus . A J Physiol Biochem Pharmacol. 2015; 4(1): 13-17. doi:10.5455/jib.20150331115356



Vancouver/ICMJE Style

Mohamedi Begum, Ashok Kumar J., Hilda Priya DSouza, Sushith Sushith, Prathima M.B, Reshma S., Shashikala M.D, Manjula Anil, Suriyan S Nair, Kavitha Ashok Kumar. Myeloperoxidase, Malondialdehyde and serum Lipids in type 2 diabetes mellitus . A J Physiol Biochem Pharmacol. (2015), [cited November 18, 2018]; 4(1): 13-17. doi:10.5455/jib.20150331115356



Harvard Style

Mohamedi Begum, Ashok Kumar J., Hilda Priya DSouza, Sushith Sushith, Prathima M.B, Reshma S., Shashikala M.D, Manjula Anil, Suriyan S Nair, Kavitha Ashok Kumar (2015) Myeloperoxidase, Malondialdehyde and serum Lipids in type 2 diabetes mellitus . A J Physiol Biochem Pharmacol, 4 (1), 13-17. doi:10.5455/jib.20150331115356



Turabian Style

Mohamedi Begum, Ashok Kumar J., Hilda Priya DSouza, Sushith Sushith, Prathima M.B, Reshma S., Shashikala M.D, Manjula Anil, Suriyan S Nair, Kavitha Ashok Kumar. 2015. Myeloperoxidase, Malondialdehyde and serum Lipids in type 2 diabetes mellitus . American Journal of Physiology, Biochemistry and Pharmacology, 4 (1), 13-17. doi:10.5455/jib.20150331115356



Chicago Style

Mohamedi Begum, Ashok Kumar J., Hilda Priya DSouza, Sushith Sushith, Prathima M.B, Reshma S., Shashikala M.D, Manjula Anil, Suriyan S Nair, Kavitha Ashok Kumar. "Myeloperoxidase, Malondialdehyde and serum Lipids in type 2 diabetes mellitus ." American Journal of Physiology, Biochemistry and Pharmacology 4 (2015), 13-17. doi:10.5455/jib.20150331115356



MLA (The Modern Language Association) Style

Mohamedi Begum, Ashok Kumar J., Hilda Priya DSouza, Sushith Sushith, Prathima M.B, Reshma S., Shashikala M.D, Manjula Anil, Suriyan S Nair, Kavitha Ashok Kumar. "Myeloperoxidase, Malondialdehyde and serum Lipids in type 2 diabetes mellitus ." American Journal of Physiology, Biochemistry and Pharmacology 4.1 (2015), 13-17. Print. doi:10.5455/jib.20150331115356



APA (American Psychological Association) Style

Mohamedi Begum, Ashok Kumar J., Hilda Priya DSouza, Sushith Sushith, Prathima M.B, Reshma S., Shashikala M.D, Manjula Anil, Suriyan S Nair, Kavitha Ashok Kumar (2015) Myeloperoxidase, Malondialdehyde and serum Lipids in type 2 diabetes mellitus . American Journal of Physiology, Biochemistry and Pharmacology, 4 (1), 13-17. doi:10.5455/jib.20150331115356





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