E-ISSN 2578-7322
 

Original Research 


Study and Characterization of the Antioxidant Activity of the Inclusion Complex of Apigenin with β-Cyclodextrin and HP-β-Cyclodextrin in solution

Jinxia Li.

Cited by (5)

Abstract
The formation of the complexes of Apigenin with β-Cyclodextrin (β-CD) and HP-β-Cyclodextrin (HP-β-CD) were studied by fluorescence spectra in solution. The formation constants (Ks) of complexes were determined by fluorescence method and Phase-solubility measurements. The results showed that the inclusion ability of β-Cyclodextrin and its derivative were the order: HP-β-CD> β-CD. In addition, the experimental resulted confirmed the existence of 1:1 inclusion complex of Apigenin with Cyclodextrins.
Kinetic studies of Scavenging of DPPH free radical with Apigenin and Cyclodextrins complexes were done. The results obtained indicated that the Apigenin/HP-β-CD complex was the most reactive form, then was β-CD complex, and last was free Apigenin.

Key words: Apigenin; Cyclodextrins; Fluorescence; DPPH•


 
ARTICLE TOOLS
Abstract
PDF Fulltext
Print this article Print this Article
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Jinxia Li
on Google
on Google Scholar
Article Statistics
 Viewed: 1849
Downloaded: 518
Cited: 5

REFERENCES
1. Peterson J, Dwyer J. Flavonoids: Dietary occurrence and biochemicalactivity. Nu tr Res 1998;18:1995-2018. [DOI via Crossref]   
2. Havsteen BH. The biochemistry and medical significance of theflavonoids. Pharmacol Ther 2002;96:67-202. [DOI via Crossref]   
3. Funakoshi-Tago M, Nakamura K, Tago K, Mashino T, Kasahara T.Anti-inflammatory activity of structurally related flavonoids, apigenin,luteolin and fisetin. Int Immunopharmacol 2011;11:1150-9. [DOI via Crossref]    [Pubmed]   
4. Horvathova K, Novotny L, Vachalkova A. The free radical scavengingactivity of four flavonoids determined by the comet assay. Neoplasma2003;50:291-5. [Pubmed]   
5. Yin F, Giuliano AE, Law RE, Van Herle AJ. Apigenin inhibits growthand induces G2/M arrest by modulating cyclin-CDK regulators andERK MAP kinase activation in breast carcinoma cells. Anticancer Res2001;21:413-20. [Pubmed]   
6. Wang W, Heideman L, Chung CS, Pelling JC, Koehler KJ, Birt DF.Cell-cycle arrest at G2/M and growth inhibition by apigenin in humancolon carcinoma cell lines. Mol Carcinog 2000;28:102-10. [DOI via Crossref]   
7. Tong X, Van Dross RT, Abu-Yousif A, Morrison AR, Pelling JC. Apigeninprevents UVB-induced cyclooxygenase 2 expression: coupled mRNAstabilization and translational inhibition. Mol Cell Biol 2007;27:283-96. [DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   
8. Takahashi T, Kobori M, Shinmoto H, Tsushida T. Structure-activityrelationships of flavonoids and the induction of granulocytic- ormonocytic-differentiation in HL60 human myeloid leukemia cells.Biosci Biotechnol Biochem 1998;62:2199-204. [DOI via Crossref]    [Pubmed]   
9. Ujiki MB, Ding XZ, Salabat MR, Bentrem DJ, Golkar L, Milam B, et al.Apigenin inhibits pancreatic cancer cell proliferation through G2/Mcell cycle arrest. Mol Cancer 2006;5:76. [DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   
10. WesoÅ,owska O, Hendrich AB, Lania-Pietrzak B, Wisniewski J, Molnar J,Ocsovszki I, et al. Perturbation of the lipid phase of a membrane is notinvolved in the modulation of MRP1 transport activity by flavonoids.Cell Mol Biol Lett 2009;14:199-221. [DOI via Crossref]    [Pubmed]   
11. Ollila F, Halling K, Vuorela P, Vuorela H, Slotte JP. Characterizationof flavonoid - Biomembrane interactions. Arch Biochem Biophys2002;399:103-8. [DOI via Crossref]    [Pubmed]   
12. Tsuchiya H, Nagayama M, Tanaka T, Furusawa M, Kashimata M,Takeuchi H. Membrane-rigidifying effects of anti-cancer dietaryfactors. Biofactors 2002;16:45-56. [DOI via Crossref]    [Pubmed]   
13. Hwang TC, Koeppe RE 2nd, Andersen OS. Genistein can modulatechannel function by a phosphorylation-independent mechanism:Importance of hydrophobic mismatch and bilayer mechanics.Biochemistry 2003;42:13646-58. [DOI via Crossref]    [Pubmed]   
14. Liu L, Yang T, Simon SA. The protein tyrosine kinase inhibitor, genistein,decreases excitability of nociceptive neurons. Pain 2004;112:131-41. [DOI via Crossref]    [Pubmed]   
15. Pawlikowska-Pawlega B, Misiak LE, Zarzyka B, Paduch R, Gawron A,Gruszecki WI. FTIR, (1) H NMR and EPR spectroscopy studies on theinteraction of flavone apigenin with dipalmitoylphosphatidylcholineliposomes. Biochim Biophys Acta 2013;1828:518-27. [DOI via Crossref]    [Pubmed]   
16. Gates MA, Tworoger SS, Hecht JL, De Vivo I, Rosner B, Hankinson SE.A prospective study of dietary flavonoid intake and incidence ofepithelial ovarian cancer. Int J Cancer 2007;121:2225-32. [DOI via Crossref]    [Pubmed]   
17. Gates MA, Vitonis AF, Tworoger SS, Rosner B, Titus-Ernstoff L,Hankinson SE, et al. Flavonoid intake and ovarian cancer risk in apopulation-based case-control study. Int J Cancer 2009;124:1918-25. [DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   
18. Hamilton TD, Papaefstathiou GS, MacGillivray LR. Templatecontrolledreactivity: Following nature’s way to design and constructmetal-organic polyhedra and polygons. J Solid State Chem2005;178:2409-13. [DOI via Crossref]   
19. Tang JJ, Cline Love LJ. Formation constants o polynuclear aromaticcompounds and β-cyclodextrin inclusion complexes in β-cyclodextrinmodified mobile phase high performance liquid chromatographysystem. Anal Chim Acta 1997;344:137-43. [DOI via Crossref]   
20. Cortes ME, Sinisterra RD, Avilacampos MJ, Tortamano N, Rocha RG.The chlorhexidine: β-cyclodextrin inclusion compound: preparation,characterization and microbiological evaluation. J Incl PhenomMacrocycl Chem 2001;40:297-302. [DOI via Crossref]   
21. Hergert LA, Escandar GM. Spectrofluorimetric study of the betacyclodextrin-ibuprofen complex and determination of ibuprofen inpharmaceutical preparations and serum. Talanta 2003;60:235-46. [DOI via Crossref]   
22. Durán Merás I, Espinosa-Mansilla A, Rodríguez DA Complexationstudy of cinalukast and montelukast with cyclodextrines. J PharmBiomed Anal 2007;43:1025-32. [DOI via Crossref]    [Pubmed]   
23. Lucas-Abella′n C, Fortea I, Lo′pez-Nicola′s JM, Estrella N.Cyclodextrins as resveratrol carrier system. Food Chem2007;104:39-44.
24. Kokkinou A, Makedonopoulou S, Mentzafos D. The crystal structureof the 1:1 complex of beta-cyclodextrin with trans-cinnamic acid.Carbohydr Res 2000;328:135-40. [DOI via Crossref]   
25. George K, Willingham V, Wu H, Gridley D, Nelson G, Cucinotta FA.Chromosome aberrations in human lymphocytes induced by 250MeV protons: Effects of dose, dose rate and shielding. Adv SpaceRes 2002;30:891-9. [DOI via Crossref]   
26. Arancibia JA, Escandar GM. Two different strategies for the fluorimetricdetermination of piroxicam in serum. Talanta 2003;60:1113-21. [DOI via Crossref]   
27. Betts TA, Catena GC, Huang J, Litwiler KS, Zhang J, Zagrobelny J,et al. Bright Fiber-optic-based immunosensors for haptens. Anal ChimActa 1991;246:55-63. [DOI via Crossref]   
28. Escandar GM, Gómez DG, Mansilla AE, Mu-ozdela Pe-a A,Goicoechea HC. Determination o carbamazepine in serum andpharmaceutical preparations using immobilization on a nylon supportand fluorescence detection. Anal Chim Acta 2004;506:161-70. [DOI via Crossref]   
29. Eklund PC, Långvik OK, Wärnå JP, Salmi TO, Willför SM,Sjöholm RE. Chemical studies on antioxidant mechanisms andfree radical scavenging properties of lignans. Org Biomol Chem2005;3:3336-47. [DOI via Crossref]    [Pubmed]   
30. Alma MH, Mavi A, Yildirim A, Digrak M, Hirata T. Screening chemicalcomposition and in vitro antioxidant and antimicrobial activities ofthe essential oils from Origanum syriacum L. growing in Turkey. BiolPharm Bull 2003;26:1725-9. [DOI via Crossref]   
31. Karioti A, Hadjipavlou-Litina D, Mensah ML, Fleischer TC, Skaltsa H.Composition and antioxidant activity of the essential oils of Xylopiaaethiopica (Dun) A. Rich. (Annonaceae) leaves, stem bark, root bark,and fresh and dried fruits, growing in Ghana. J Agric Food Chem2004;52:8094-8. [DOI via Crossref]    [Pubmed]   
32. Kordali S, Cakir A, Mavi A, Kilic H, Yildirim A. Screening of chemicalcomposition and antifungal and antioxidant activities of the essentialoils from three Turkish Artemisia species. J Agric Food Chem2005;53:1408-16. [DOI via Crossref]    [Pubmed]   
33. Shanga Y, Lia H. Studies of the interaction between apigenin andbovine serum albumin by spectroscopic methods. Russian J GenChem 2010;80:1710-7. [DOI via Crossref]   
34. Higuchi T, Connors KA. Phase solubility techniques. Adv Anal ChemInstrum 1965;4:117-212.
35. Ozcelik B, Lee JH, Min DB. Effects of light, oxygen, and pH onthe absorbance of 2, 2-diphenyl-1-picrylhydrazyl. J Food Sci2003;68:487-90. [DOI via Crossref]   
36. Mimica-Dukic N, Bozin B, Sokovic M, Simin N. Antimicrobial andantioxidant activities of Melissa officinalis L. (Lamiaceae) essentialoil. J Agric Food Chem 2004;52:2485-9. [DOI via Crossref]    [Pubmed]   
37. Connors KA. Binding Constants. The Measurement of MolecularComplex Stability. New York: Wiley; 1987.
38. Saito S, Okamoto Y, Kawabata J. Effects of alcoholic solvents onantiradical abilities of protocatechuic acid and its alkyl esters. BiosciBiotechnol Biochem 2004;68:1221-7. [DOI via Crossref]    [Pubmed]   
39. Shizuka S, Kawabata J. Effects of electron-withdrawing substituentson DPPH radical scavenging reactions of protocatechuic acid and itsanalogues in alcoholic solvents. Tetrahedron 2005;61:8101-8. [DOI via Crossref]   
40. Natella F, Nardini M, Di Felice M, Scaccini C. Benzoic and cinnamicacid derivatives as antioxidants: structure-activity relation. J AgricFood Chem 1999;47:1453-9. [DOI via Crossref]   

This Article Cited By the following articles

Solubility and dissolution rate improvement of the inclusion complex of apigenin with 2-hydroxypropyl-β-cyclodextrin prepared using the liquid antisolvent precipitation and solvent removal combination methods
Drug Development and Industrial Pharmacy 2017; 43(8): 1366.

1
 
Preparation, characterization and antitumor activity evaluation of apigenin nanoparticles by the liquid antisolvent precipitation technique
Drug Delivery 2017; 24(1): 1713.

2
 
Comparative evaluation of the effect of cyclodextrins and pH on aqueous solubility of apigenin
Journal of Pharmaceutical and Biomedical Analysis 2016; 117(): 210.

3
 
Preparation, in-vitro release and antioxidant potential of formulation of apigenin with hydroxypropyl-β-cyclodextrin modified microemulsion
J Incl Phenom Macrocycl Chem 2016; (): .

4
 
Comparative evaluation of the effect of cyclodextrins and pH on aqueous solubility of apigenin
Journal of Pharmaceutical and Biomedical Analysis 2015; (): .

5
 
How to Cite this Article
Pubmed Style

Jinxia Li. Study and Characterization of the Antioxidant Activity of the Inclusion Complex of Apigenin with β-Cyclodextrin and HP-β-Cyclodextrin in solution. A J Physiol Biochem Pharmacol. 2014; 3(3): 107-111. doi:10.5455/jib.20140905032504


Web Style

Jinxia Li. Study and Characterization of the Antioxidant Activity of the Inclusion Complex of Apigenin with β-Cyclodextrin and HP-β-Cyclodextrin in solution. http://www.ajpbp.com/?mno=164707 [Access: November 18, 2018]. doi:10.5455/jib.20140905032504


AMA (American Medical Association) Style

Jinxia Li. Study and Characterization of the Antioxidant Activity of the Inclusion Complex of Apigenin with β-Cyclodextrin and HP-β-Cyclodextrin in solution. A J Physiol Biochem Pharmacol. 2014; 3(3): 107-111. doi:10.5455/jib.20140905032504



Vancouver/ICMJE Style

Jinxia Li. Study and Characterization of the Antioxidant Activity of the Inclusion Complex of Apigenin with β-Cyclodextrin and HP-β-Cyclodextrin in solution. A J Physiol Biochem Pharmacol. (2014), [cited November 18, 2018]; 3(3): 107-111. doi:10.5455/jib.20140905032504



Harvard Style

Jinxia Li (2014) Study and Characterization of the Antioxidant Activity of the Inclusion Complex of Apigenin with β-Cyclodextrin and HP-β-Cyclodextrin in solution. A J Physiol Biochem Pharmacol, 3 (3), 107-111. doi:10.5455/jib.20140905032504



Turabian Style

Jinxia Li. 2014. Study and Characterization of the Antioxidant Activity of the Inclusion Complex of Apigenin with β-Cyclodextrin and HP-β-Cyclodextrin in solution. American Journal of Physiology, Biochemistry and Pharmacology, 3 (3), 107-111. doi:10.5455/jib.20140905032504



Chicago Style

Jinxia Li. "Study and Characterization of the Antioxidant Activity of the Inclusion Complex of Apigenin with β-Cyclodextrin and HP-β-Cyclodextrin in solution." American Journal of Physiology, Biochemistry and Pharmacology 3 (2014), 107-111. doi:10.5455/jib.20140905032504



MLA (The Modern Language Association) Style

Jinxia Li. "Study and Characterization of the Antioxidant Activity of the Inclusion Complex of Apigenin with β-Cyclodextrin and HP-β-Cyclodextrin in solution." American Journal of Physiology, Biochemistry and Pharmacology 3.3 (2014), 107-111. Print. doi:10.5455/jib.20140905032504



APA (American Psychological Association) Style

Jinxia Li (2014) Study and Characterization of the Antioxidant Activity of the Inclusion Complex of Apigenin with β-Cyclodextrin and HP-β-Cyclodextrin in solution. American Journal of Physiology, Biochemistry and Pharmacology, 3 (3), 107-111. doi:10.5455/jib.20140905032504





Most Viewed Articles
  • Slippery Elm, its Biochemistry, and use as a Complementary and Alternative Treatment for Laryngeal Irritation
    Christopher R Watts, Bernard rousseau
    J Investig Biochem. 2012; 1(1): 17-23
    » Abstract & References » doi: 10.5455/jib.20120417052415

  • Selected disease fundamentals based on the unified cell bioenergetics
    Andrzej Kasperski, Renata Kasperska
    J Investig Biochem. 2013; 2(2): 93-100
    » Abstract & References » doi: 10.5455/jib.20130227041230

  • Prevalence of vitamin B12 deficiency in Helicobacter pylori infected patients in Jordan.
    Saad Abed Aljalil Alfawaeir, Mohammad Basim Abuzaid
    J Investig Biochem. 2013; 2(1): 21-25
    » Abstract & References » doi: 10.5455/jib.20121215061954

  • Serum levels of high-sensitivity C-reactive protein (hs-CRP) in Helicobacter pylori infected patients
    Saad Al-Fawaeir, Mohammad Basim Abu Zaid
    J Investig Biochem. 2013; 2(1): 32-36
    » Abstract & References » doi: 10.5455/jib.20121225015606

  • Molecular Characterization of Alpha and Beta Thalassemia in Yemeni Sickle Cell Disease Children
    Saeed Thabet Nasher, Mohammed Wael Abu Ghoush
    J Investig Biochem. 2013; 2(1): 44-52
    » Abstract & References » doi: 10.5455/jib.20130105022014

  • Hepatoprotective and In vivo Anti-oxidant Activity of Costus afer Leaf Extracts against Acetaminophen-Induced Hepatotoxicity in Rats
    God'swill Nduka Anyasor, Kofoworola O. Odunsanya, Audrey C. Ibeneme
    J Investig Biochem. 2013; 2(1): 53-61
    » Abstract & References » doi: 10.5455/jib.20130301030851

  • Correlation Between Elevated Hepatic Enzymes & High-Sensitivity Crp in Metabolic Syndrome.
    Al-Rubaye Faisal, Shakir Mahmood, Jumah Kadhum
    J Investig Biochem. 2012; 1(1): 6-11
    » Abstract & References » doi: 10.5455/jib.20120528094732

  • Serum Lipid Profile of Breast Cancer Patients in Kashmir
    Showkat Ahmad Bhat, Manzoor R Mir, Sabhiya Majid, Ahmad Arif Reshi, Ishraq Husain, Tehseen Hassan, Hilal Ahmad
    J Investig Biochem. 2013; 2(1): 26-31
    » Abstract & References » doi: 10.5455/jib.20121125075314

  • Alteration of antioxidant enzymes and oxidative stress in elderly patient.
    Seema L. Jawalekar1, Anil K. Bhutey2, Aarti Karnik3, Vasant T. Surve4
    J Investig Biochem. 2013; 2(1): 37-43
    » Abstract & References » doi: 10.5455/jib.20130129093838

  • Potential Role of Oxidized LDL (ox-LDL) and Adhesion Molecules (VCAM-1, ICAM-1) in Type 2 Diabetes Mellitus Patients in Qassim region, KSA
    Manal Basyouni, Maha Ahmed, Hisham Ismail , Iman Esmat
    J Investig Biochem. 2012; 1(1): 48-54
    » Abstract & References » doi: 10.5455/jib.20120417052458

  • Most Downloaded
  • Slippery Elm, its Biochemistry, and use as a Complementary and Alternative Treatment for Laryngeal Irritation
    Christopher R Watts, Bernard rousseau
    J Investig Biochem. 2012; 1(1): 17-23
    » Abstract & References » doi: 10.5455/jib.20120417052415

  • Selected disease fundamentals based on the unified cell bioenergetics
    Andrzej Kasperski, Renata Kasperska
    J Investig Biochem. 2013; 2(2): 93-100
    » Abstract & References » doi: 10.5455/jib.20130227041230

  • Serum levels of high-sensitivity C-reactive protein (hs-CRP) in Helicobacter pylori infected patients
    Saad Al-Fawaeir, Mohammad Basim Abu Zaid
    J Investig Biochem. 2013; 2(1): 32-36
    » Abstract & References » doi: 10.5455/jib.20121225015606

  • Alteration of antioxidant enzymes and oxidative stress in elderly patient.
    Seema L. Jawalekar1, Anil K. Bhutey2, Aarti Karnik3, Vasant T. Surve4
    J Investig Biochem. 2013; 2(1): 37-43
    » Abstract & References » doi: 10.5455/jib.20130129093838

  • Serum Lipid Profile of Breast Cancer Patients in Kashmir
    Showkat Ahmad Bhat, Manzoor R Mir, Sabhiya Majid, Ahmad Arif Reshi, Ishraq Husain, Tehseen Hassan, Hilal Ahmad
    J Investig Biochem. 2013; 2(1): 26-31
    » Abstract & References » doi: 10.5455/jib.20121125075314

  • Hepatoprotective and In vivo Anti-oxidant Activity of Costus afer Leaf Extracts against Acetaminophen-Induced Hepatotoxicity in Rats
    God'swill Nduka Anyasor, Kofoworola O. Odunsanya, Audrey C. Ibeneme
    J Investig Biochem. 2013; 2(1): 53-61
    » Abstract & References » doi: 10.5455/jib.20130301030851

  • Evaluation of glycated albumin and microalbuminuria as early risk markers of nephropathy in type 2 diabetes mellitus
    Suresh Babu Kondaveeti, Ivvala Anand Shaker
    J Investig Biochem. 2013; 2(2): 127-131
    » Abstract & References » doi: 10.5455/jib.20130507061739

  • Comparative study of ischemia modified albumin and nitric oxide in hyperthyroidism
    Monica Verma1, Kiran Dahiya1, Veena Singh Ghalaut1, Abhishek Soni2, Jagjeet Singh3, Vasudha Dhupper1
    J Investig Biochem. 2014; 3(1): 17-20
    » Abstract & References » doi: 10.5455/jib.20130707090209

  • Prevalence of vitamin B12 deficiency in Helicobacter pylori infected patients in Jordan.
    Saad Abed Aljalil Alfawaeir, Mohammad Basim Abuzaid
    J Investig Biochem. 2013; 2(1): 21-25
    » Abstract & References » doi: 10.5455/jib.20121215061954

  • Serum lipid profile in Helicobacter pylori infected patients
    Saad Al-Fawaeir, Mohammad Abu Zaid, Ayman Abu Awad, Baker Alabedallat
    J Investig Biochem. 2013; 2(2): 132-135
    » Abstract & References » doi: 10.5455/jib.20130603084538

  • Most Cited Articles
  • Biochemical study on the impact of Nigella sativa and virgin olive oils on cadmium-induced nephrotoxicity and neurotoxicity in rats
    Eman Taha Mohammed, Khalid Shaban Hashem, Mahmoud Ramadan Abdel Rheim
    J Investig Biochem. 2014; 3(2): 71-78
    » Abstract & References » doi: 10.5455/jib.20140716041908
    Cited : 6 times [Click to see citing articles]

  • Study and Characterization of the Antioxidant Activity of the Inclusion Complex of Apigenin with β-Cyclodextrin and HP-β-Cyclodextrin in solution
    Jinxia Li
    J Investig Biochem. 2014; 3(3): 107-111
    » Abstract & References » doi: 10.5455/jib.20140905032504
    Cited : 5 times [Click to see citing articles]

  • Slippery Elm, its Biochemistry, and use as a Complementary and Alternative Treatment for Laryngeal Irritation
    Christopher R Watts, Bernard rousseau
    J Investig Biochem. 2012; 1(1): 17-23
    » Abstract & References » doi: 10.5455/jib.20120417052415
    Cited : 4 times [Click to see citing articles]

  • Alterations in plasma lipids, glutathione and homocysteine in relation to dietary copper in rats
    Magda A. Megahed1, Kamel M. A. Hassanin2, Ibrahim M. I. Youssef3, Abdul Baset A. Elfghi4, Kamal A. Amin2
    J Investig Biochem. 2014; 3(1): 21-25
    » Abstract & References » doi: 10.5455/jib.20130716075753
    Cited : 4 times [Click to see citing articles]

  • Quercetin, a natural phytochemical and antioxidant protects against sodium azide-induced hepatic and splenic oxidative stress in rats
    Oluwatobi Temitope Somade, Oluseyi Adeboye Akinloye, Michael Oluwayemi Adeyeye, Gbenga Daniel Fabunmi, Olakunle Opeoluwa Idowu, Funmilayo Oluwaseun Badmus, Barakat Oluwatoyin Salaudeen
    J Investig Biochem. 2015; 4(3): 69-74
    » Abstract & References » doi: 10.5455/jib.20151220014400
    Cited : 3 times [Click to see citing articles]

  • A New Marker For The Diagnoss Of Sepsis: Presepsin
    Mehmet Agilli, Irfan Sener, Fatih Yesildal, Tevfik Honca, Ibrahim Aydin, Emin Ozgur Akgul, Halil Yaman
    J Investig Biochem. 2012; 1(1): 55-57
    » Abstract & References » doi: 10.5455/jib.20120521073837
    Cited : 3 times [Click to see citing articles]

  • The role of urinary 5- hydroxyindoleacetic acid determination in diagnosis of acute appendicitis
    Hamid Hindi Sarhan, Aseel Fawzi Hatroosh, Amina Hamed Alobaidi
    J Investig Biochem. 2013; 2(1): 1-5
    » Abstract & References » doi: 10.5455/jib.20121026084836
    Cited : 3 times [Click to see citing articles]

  • Serum Lipid Profile of Breast Cancer Patients in Kashmir
    Showkat Ahmad Bhat, Manzoor R Mir, Sabhiya Majid, Ahmad Arif Reshi, Ishraq Husain, Tehseen Hassan, Hilal Ahmad
    J Investig Biochem. 2013; 2(1): 26-31
    » Abstract & References » doi: 10.5455/jib.20121125075314
    Cited : 3 times [Click to see citing articles]

  • Phytochemical content of Cnidoscolus aconitifolius leaves and toxicological effect of its aqueous leaf extract in Wistar rats
    Doris Akachukwu, Polycarp Nnacheta Okafor, Chiedozie O Ibegbulem
    J Investig Biochem. 2014; 3(1): 26-31
    » Abstract & References » doi: 10.5455/jib.20140504023102
    Cited : 3 times [Click to see citing articles]

  • Myeloperoxidase, Malondialdehyde and serum Lipids in type 2 diabetes mellitus
    Mohamedi Begum, Ashok Kumar J., Hilda Priya D'Souza, Sushith Sushith, Prathima M.B, Reshma S., Shashikala M.D, Manjula Anil, Suriyan S Nair, Kavitha Ashok Kumar
    J Investig Biochem. 2015; 4(1): 13-17
    » Abstract & References » doi: 10.5455/jib.20150331115356
    Cited : 3 times [Click to see citing articles]