E-ISSN 2578-7322
 

Original Research 


Alterations in some organ function indices in rats administered metal complexes of ofloxacin and norfloxacin

Joseph O. Adebayo, Elizabeth A. Balogun, O. Ajadi, Caroline A. Akinremi, Joshua A. Obaleye.

Abstract
Background. Some metal complexes of norfloxacin and ofloxacin have been synthesized and found to be more potent than their free ligands but have not been evaluated for their toxicities.
Objective. Effects of ofloxacin, norfloxacin and their metal complexes (nickel, copper and iron complexes) on kidney and liver function indices in rats were investigated. Methods. Ofloxacin and its metal complexes (2.86 mg/Kg body weight twice daily) and norfloxacin and its nickel complex (5.71 mg/Kg body weight twice daily) were orally administered to rats while the control animals received sterile distilled water for seven days. Afterwards, concentrations of selected serum electrolytes and biomolecules were determined.
Results. Ofloxacin significantly reduced (P<0.05) serum calcium ion, urea and total protein concentrations while it significantly increased (P<0.05) the atherogenic index compared to controls. Cuprate (II) hydrate complex of ofloxacin significantly increased (P<0.05) serum glucose concentration while it significantly reduced (P<0.05) serum inorganic phosphate concentration compared to controls. Iron (III) complex of ofloxacin had no significant effect (P>0.05) on all the parameters studied compared to controls. Norfloxacin significantly increased (P<0.05) serum glucose concentration while it significantly reduced (P<0.05) serum potassium ion concentration compared to controls. Nickel (II) complex of norfloxacin significantly reduced (P<0.05) serum creatinine and inorganic phosphate concentrations compared to controls.
Conclusion. The results of this study suggest that Iron (III) complex of ofloxacin may be a less toxic therapeutic option compared to ofloxacin.

Key words: Fluoroquinolones, Cardiovascular, Kidney, Liver, Toxicity


 
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REFERENCES
1. Khan JA, Iqbal Z, Rahman SU, Farzana K, Khan A. Report: Prevalence and resistance pattern of Pseudomonas aeruginosa against various antibiotics. Pak J Pharm Sci 2008;21:311-5. [Pubmed]   
2. De Sarro A, De Sarro G. Adverse reactions to fluoroquinolones. an overview on mechanistic aspects. Curr Med Chem 2001;8:371-84. [DOI via Crossref]    [Pubmed]   
3. Cornaglia G, Concan R, Arrigucci S, Novelli A. Antibacterial activity and pharmacological features of fluoroquinolones and considerations on their use in a nosocomial setting. Infez Med 2007;15:211-36. [Pubmed]   
4. Maxwell A. The molecular basis of quinolone action. J Antimicrob Chemother 1992;30:409-14. [DOI via Crossref]    [Pubmed]   
5. Palù G, Valisena S, Ciarrocchi G, Gatto B, Palumbo M. Quinolone binding to DNA is mediated by magnesium ions. Proc Natl Acad Sci U S A 1992;89:9671-5. [DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   
6. Rosenthal PJ. Antimalarial drug discovery: Old and new approaches. J Exp Biol 2003;206:3735-44. [DOI via Crossref]    [Pubmed]   
7. Lomaestro BM, Bailie GR. Absorption interactions with fluoroquinolones 1995 update. Drug Saf 1995;12:314-33. [DOI via Crossref]   
8. Drevenski P, Golobic A, Turel I, Poklar N, Sepcic K. Crystal structure, characterization and biological activity of copper(ii)-ciprofloxacin ionic compound. Acta Chim Slov 2002;49:857-70.
9. Kawazoe H, Takaoka K, Shibata H, Arakaki N, Higuti T, Negayama K, et al. Comparison of antibacterial activity of fluoroquinolones with their sucralfate-complexes against clinically-isolated bacteria. J Health Sci 2009;55:790-5. [DOI via Crossref]   
10. Obaleye JA, Akinremi CA, Balogun EA, Adebayo JO. Toxicological studies and antimicrobial properties of some iron (III) complexes of ciprofloxacin. Afr J Biotechnol 2007;6:2826-32.
11. Turel I. The interaction of metal ions with quinolone antibacterial agents. Coord Chem Rev 2002;232:27-47. [DOI via Crossref]   
12. Obaleye JA, Akinremi CA, Balogun EA, Adebayo JO. Syntheses, characterization, antimicrobial and toxicological studies of some metal complexes of norfloxacin and ofloxacin. Centrepoint (Science Edition) 2009;16:37-56.
13. Lipsky BA, Baker CA. Fluoroquinolone toxicity profiles: A review focusing on newer agents. Clin Infect Dis 1999;28:352-64. [DOI via Crossref]    [Pubmed]   
14. Schaad UB, Wedgwood J. Lack of quinolone-induced arthropathy in children. J Antimicrob Chemother 1992;30:414-6. [DOI via Crossref]   
15. Wolfson JS, Hooper DC. Fluoroquinolone antimicrobial agents. Clin Microbiol Rev 1989;2:378-424. [Pubmed]    [PMC Free Fulltext]   
16. Wilcox MH. Ten years of ciprofloxacin: The past, present and future. Serious hospital infections. Introduction. J Antimicrob Chemother 1999;43 Suppl A:115.
17. Halkin H. Adverse effects of the fluoroquinolones. Rev Infect Dis 1988;10 Suppl 1:S258-61. [DOI via Crossref]    [Pubmed]   
18. National Research Council. Institute of Laboratory Animal Resources Commission in Life Sciences. Washington, DC: National Academy Press; 1996.
19. Narayanan CR, Joshi DD, Maunder AM. Hypoglycemic action of Bougainvillea spectabilis leaves. Curr Sci 1984;53:579-81.
20. Ogbu SI, Okechukwu EI. The effect of storage temperature prior to separation on plasma and serum potassium. J Med Lab Sci 2001;10:1-4.
21. Tietz NW, Pruden EL, Siggaard-Anderson O. In: Burtis GA, Ashwood ER, editors. Tietz Textbook of Clinical Chemistry. London: W.B. Saunders Company; 1994. p. 1354-74.
22. Fredrickson DS, Levy RI, Lees RS. Fat transport in lipoproteins – An integrated approach to mechanisms and disorders. N Engl J Med 1967;276:148-56. [DOI via Crossref]    [Pubmed]   
23. Albers JJ, Warnick GR, Chenng MC. Quantitation of high density lipoproteins. Lipids 1978;13:926-32. [DOI via Crossref]    [Pubmed]   
24. Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 1972;18:499-502. [Pubmed]   
25. Gornall AG, Bardawill CJ, David MM. Determination of serum proteins by means of the biuret reaction. J Biol Chem 1949;177:751-66. [Pubmed]   
26. Veniamin MP, Vakirtzi-Lemonias C. Chemical basis of the carbamidodiacetyl micromethod for estimation of urea, citrulline, and carbamyl derivatives. Clin Chem 1970;16:3-6. [Pubmed]   
27. Cook JG, Association of clinical Biochemists' Scientific and Technica Committee. Factors influencing the assay of creatinine. Ann Clin Biochem 1975;12:219-32. [DOI via Crossref]    [Pubmed]   
28. Grant GH, Kachmar JF. In: Tietz NW, editor. Fundamentals of Clinical Chemistry. 3rd ed. W.B. Philadelphia: Saunders Company; 1987. p. 298-320.
29. Goldenberg H, Fernandez A. Simplified method for the estimation of inorganic phosphorus in body fluids. Clin Chem 1966;12:871-82. [Pubmed]   
30. Sarkar BC, Chauhan UP. A new method for determining micro quantities of calcium in biological materials. Anal Biochem 1967;20:155-66. [DOI via Crossref]   
31. Montgomery DC. Design and Analysis of Experiment. New York: John Wiley; 1976. p. 48-50.
32. Smith GL, Shlipak MG, Havranek EP, Foody JM, Masoudi FA, Rathore SS, et al. Serum urea nitrogen, creatinine, and estimators of renal function: Mortality in older patients with cardiovascular disease. Arch Intern Med 2006;166:1134-42. [DOI via Crossref]    [Pubmed]   
33. Marshall WJ, Bangert SK. Clinical Chemistry. Edinburgh: Mosby Elsevier; 2008.
34. Wyss M, Kaddurah-Daouk R. Creatine and creatinine metabolism. Physiol Rev 2000;80:1107-213. [Pubmed]   
35. Miller LL, Bly CG, Watson ML, Bale WF. The dominant role of the liver in plasma protein synthesis; a direct study of the isolated perfused rat liver with the aid of lysine-epsilon-C14. J Exp Med 1951;94:431-53. [DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   
36. Lundsgaard-Hansen P. Physiology and pathophysiology of colloid osmotic pressure and albumin metabolism. Curr Stud Hematol Blood Transfus 1986;:1-17. [Pubmed]   
37. De Feo P, Gaisano MG, Haymond MW. Differential effects of insulin deficiency on albumin and fibrinogen synthesis in humans. J Clin Invest 1991;88:833-40. [DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   
38. Kazi-Aoul T, Benmiloud M. The Friedewald formula: Another restriction? Clin Chem 1987;33:1301 [Pubmed]   

How to Cite this Article
Pubmed Style

Joseph O. Adebayo, Elizabeth A. Balogun, O. Ajadi, Caroline A. Akinremi, Joshua A. Obaleye. Alterations in some organ function indices in rats administered metal complexes of ofloxacin and norfloxacin. A J Physiol Biochem Pharmacol. 2014; 3(4): 159-163. doi:10.5455/jib.20141119115356


Web Style

Joseph O. Adebayo, Elizabeth A. Balogun, O. Ajadi, Caroline A. Akinremi, Joshua A. Obaleye. Alterations in some organ function indices in rats administered metal complexes of ofloxacin and norfloxacin. http://www.ajpbp.com/?mno=165159 [Access: December 13, 2018]. doi:10.5455/jib.20141119115356


AMA (American Medical Association) Style

Joseph O. Adebayo, Elizabeth A. Balogun, O. Ajadi, Caroline A. Akinremi, Joshua A. Obaleye. Alterations in some organ function indices in rats administered metal complexes of ofloxacin and norfloxacin. A J Physiol Biochem Pharmacol. 2014; 3(4): 159-163. doi:10.5455/jib.20141119115356



Vancouver/ICMJE Style

Joseph O. Adebayo, Elizabeth A. Balogun, O. Ajadi, Caroline A. Akinremi, Joshua A. Obaleye. Alterations in some organ function indices in rats administered metal complexes of ofloxacin and norfloxacin. A J Physiol Biochem Pharmacol. (2014), [cited December 13, 2018]; 3(4): 159-163. doi:10.5455/jib.20141119115356



Harvard Style

Joseph O. Adebayo, Elizabeth A. Balogun, O. Ajadi, Caroline A. Akinremi, Joshua A. Obaleye (2014) Alterations in some organ function indices in rats administered metal complexes of ofloxacin and norfloxacin. A J Physiol Biochem Pharmacol, 3 (4), 159-163. doi:10.5455/jib.20141119115356



Turabian Style

Joseph O. Adebayo, Elizabeth A. Balogun, O. Ajadi, Caroline A. Akinremi, Joshua A. Obaleye. 2014. Alterations in some organ function indices in rats administered metal complexes of ofloxacin and norfloxacin. American Journal of Physiology, Biochemistry and Pharmacology, 3 (4), 159-163. doi:10.5455/jib.20141119115356



Chicago Style

Joseph O. Adebayo, Elizabeth A. Balogun, O. Ajadi, Caroline A. Akinremi, Joshua A. Obaleye. "Alterations in some organ function indices in rats administered metal complexes of ofloxacin and norfloxacin." American Journal of Physiology, Biochemistry and Pharmacology 3 (2014), 159-163. doi:10.5455/jib.20141119115356



MLA (The Modern Language Association) Style

Joseph O. Adebayo, Elizabeth A. Balogun, O. Ajadi, Caroline A. Akinremi, Joshua A. Obaleye. "Alterations in some organ function indices in rats administered metal complexes of ofloxacin and norfloxacin." American Journal of Physiology, Biochemistry and Pharmacology 3.4 (2014), 159-163. Print. doi:10.5455/jib.20141119115356



APA (American Psychological Association) Style

Joseph O. Adebayo, Elizabeth A. Balogun, O. Ajadi, Caroline A. Akinremi, Joshua A. Obaleye (2014) Alterations in some organ function indices in rats administered metal complexes of ofloxacin and norfloxacin. American Journal of Physiology, Biochemistry and Pharmacology, 3 (4), 159-163. doi:10.5455/jib.20141119115356





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