E-ISSN 2578-7322
 

Original Research 


Correlation Between Elevated Hepatic Enzymes & High-Sensitivity Crp in Metabolic Syndrome.

Al-Rubaye Faisal, Shakir Mahmood, Jumah Kadhum.

Abstract
BACKGROUND AND OBJECTIVES:
The phrase "metabolic syndrome" was used to describe the joint incidence of hyperlipoproteinemia, diabetes, hypertension, gout and obesity in combination with an increased incidence of cardiovascular disease, fatty liver and cholelithiasis. Chronic, sub-clinical inflammation and its association with Metabolic Syndrome are well documented.. Fatty liver is now believed to be an integral part of the metabolic syndrome, since it has been shown to be independently related to insulin resistance independent of obesity and abdominal adiposity.
Aim: to assess the status of high-sensitive C reactive protein and hepatic enzymes in patients’ with Metabolic Syndrome.
METHODS: This study is a case-control study based on New National Cholesterol Education Programme Adult Treatment Panel III which approved the criteria of metabolic syndrome.
Forty-eight (48) patients ( of both sexes ) attending the Diabetic Consultant Clinic for follow up and monitoring therapy during the period from January, 2010 till the end of September, 2010; and forty-eight (48) apparently healthy volunteer that were comparable to patients group with respect to age and sex and serve as a control group were included in this study. They were screened for Metabolic Syndrome criteria: namely, high blood pressure, high body mass index, high fasting blood sugar, high triglyceride, low high density lipoprotein; a significant difference was found between patients and controls with respect to blood pressure, body mass index, fasting blood sugar, triglyceride, and high density lipoprotein (P<o.o5). For the two groups high-sensitive C reactive protein and hepatic enzymes (alanine aminotransferase, aspartate aminotransferase, gamma glutammyl transferase and alkaline phosphatase) was measured using Enzyme Linked ImmunoSorbant Assay kit and colorimetric method respectively.
The results:
Blood pressure, body mass index were significantly higher in the Metabolic Syndrome than the control. Metabolic Syndrome group had significantly higher level of high-sensitive C reactive protein as well as higher level of hepatic enzymes than control group, (p < 0.001) and significantly higher levels of Low Density Lipoprotein-Cholesterol, triglyceride (TG), but lower High Density Lipoprotein-Cholesterol than the control group.
Also high-sensitive C reactive protein showed a positive correlation with elevated hepatic enzymes (p < 0.001).
In conclusion, Elevations in liver enzymes are correlated with higher serum concentrations of high-sensitive C reactive protein in Metabolic Syndrome.

Key words: Metabolic Syndrome, hsCRP, Hepatic Enzymes .


 
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How to Cite this Article
Pubmed Style

Al-Rubaye Faisal, Shakir Mahmood, Jumah Kadhum. Correlation Between Elevated Hepatic Enzymes & High-Sensitivity Crp in Metabolic Syndrome.. A J Physiol Biochem Pharmacol. 2012; 1(1): 6-11. doi:10.5455/jib.20120528094732


Web Style

Al-Rubaye Faisal, Shakir Mahmood, Jumah Kadhum. Correlation Between Elevated Hepatic Enzymes & High-Sensitivity Crp in Metabolic Syndrome.. http://www.ajpbp.com/?mno=17902 [Access: November 18, 2018]. doi:10.5455/jib.20120528094732


AMA (American Medical Association) Style

Al-Rubaye Faisal, Shakir Mahmood, Jumah Kadhum. Correlation Between Elevated Hepatic Enzymes & High-Sensitivity Crp in Metabolic Syndrome.. A J Physiol Biochem Pharmacol. 2012; 1(1): 6-11. doi:10.5455/jib.20120528094732



Vancouver/ICMJE Style

Al-Rubaye Faisal, Shakir Mahmood, Jumah Kadhum. Correlation Between Elevated Hepatic Enzymes & High-Sensitivity Crp in Metabolic Syndrome.. A J Physiol Biochem Pharmacol. (2012), [cited November 18, 2018]; 1(1): 6-11. doi:10.5455/jib.20120528094732



Harvard Style

Al-Rubaye Faisal, Shakir Mahmood, Jumah Kadhum (2012) Correlation Between Elevated Hepatic Enzymes & High-Sensitivity Crp in Metabolic Syndrome.. A J Physiol Biochem Pharmacol, 1 (1), 6-11. doi:10.5455/jib.20120528094732



Turabian Style

Al-Rubaye Faisal, Shakir Mahmood, Jumah Kadhum. 2012. Correlation Between Elevated Hepatic Enzymes & High-Sensitivity Crp in Metabolic Syndrome.. American Journal of Physiology, Biochemistry and Pharmacology, 1 (1), 6-11. doi:10.5455/jib.20120528094732



Chicago Style

Al-Rubaye Faisal, Shakir Mahmood, Jumah Kadhum. "Correlation Between Elevated Hepatic Enzymes & High-Sensitivity Crp in Metabolic Syndrome.." American Journal of Physiology, Biochemistry and Pharmacology 1 (2012), 6-11. doi:10.5455/jib.20120528094732



MLA (The Modern Language Association) Style

Al-Rubaye Faisal, Shakir Mahmood, Jumah Kadhum. "Correlation Between Elevated Hepatic Enzymes & High-Sensitivity Crp in Metabolic Syndrome.." American Journal of Physiology, Biochemistry and Pharmacology 1.1 (2012), 6-11. Print. doi:10.5455/jib.20120528094732



APA (American Psychological Association) Style

Al-Rubaye Faisal, Shakir Mahmood, Jumah Kadhum (2012) Correlation Between Elevated Hepatic Enzymes & High-Sensitivity Crp in Metabolic Syndrome.. American Journal of Physiology, Biochemistry and Pharmacology, 1 (1), 6-11. doi:10.5455/jib.20120528094732





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