E-ISSN 2578-7322
 

Original Research 


Levels of iron and magnesium in serum of Plasmodium falciparum malarial infected children in Abraka, Delta State, Nigeria

Onyesom Innocent, Osioma Ejovi, Edah Omosco Charles.

Abstract
P. falciparum invasion and destruction of red blood cells modify mineral contents in serum of infected individuals and this may contribute to the disease mortality especially among children. In this study therefore, the amount of iron, Fe and magnesium, Mg, in serum of P. falciparum infected children were estimated to provide a baseline information in Abraka, a university community in Delta state, Nigeria. Twenty five P. falciparum infected children and twenty five uninfected children in apparent good health were screened and selected after obtaining informed consent from their parents. Serum Mg and Fe levels were estimated using established procedures and standard methods. Results shows that P. falciparum malarial infection significantly (p<0.05) reduced Mg (1.18±0.42 mEq/L) and Fe (0.46±0.15 mg/L) concentrations in a trend that depends on the malarial severity, when compared with values (Mg= 2.10+0.56 mEq/L; Fe= 1.31±0.37 mg/L) obtained from the uninfected children. Thus, P. falciparum malarial infection reduces Mg and Fe concentrations and this alter Fe and Mg – dependent metabolic and cellular activities to the detriment of the infected patient. Therefore, the experimental and clinical outcome of including Mg and Fe supplements to the anti malarial chemotherapeutic regimen should be validated in further studies.

Key words: Magnesium, Iron, P. falciparum, Abraka, Malaria


 
ARTICLE TOOLS
Abstract
PDF Fulltext
Print this article Print this Article
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Onyesom Innocent
Articles by Osioma Ejovi
Articles by Edah Omosco Charles
on Google
on Google Scholar
Article Statistics
 Viewed: 2369
Downloaded: 675
Cited: 0

REFERENCES
1. Jeffrey S, Pia M. The economic and social burden of malaria. Nature. 2002;415:680-5. [DOI via Crossref]    [Pubmed]   
2. Nzeyimana I, Henry MC, Dossou–Yovo J, Doannio JM, Diawara L, Carnevale P. Epidemiology of malaria in the southwestern forest of the Ivory Coast (Tat Region). Bull Soc Pathol Exot. 2002;95(2):89-94. [Pubmed]   
3. Nyakeriga AM, Troye-Blonmberg M, Dofman JR, Alexander ND, Back R, Kortok M, Chemtai AK, Marsh K, Williams TN. Iron deficiency and malaria among children living on the cost of Kenya. J Infect Dis. 2004;190:439-47. [DOI via Crossref]    [Pubmed]   
4. Wandier K, Shell-Duncan B, McDade TW. Evaluation of iron deficiency as a nutritional adaptation to infectious disease: An evolution medicine perspective Am J Hum Biol. 2009;21(2):172-6. [DOI via Crossref]    [Pubmed]   
5. Bremen J. The ears of the Hippopotamus: Manifestation, determinants, and estimates of the malaria burden. Am J Trop Hyg. 2004;64(1,25):1-11.
6. Lymch S. Iron metabolism. In: Nutritional Anaemia. Kraemer K, Zimmermann MB (Eds.). Sight and Life Press, Basel. 2007; pp. 59-76.
7. Gindler EM, Hert DA. Colorimetric determination with bound 'calmagite' of magnesium in human blood serum (abstracted). Clin Chem. 1971:17:662.
8. Tietz NW. Fundamentals of Clinical Chemistry, Philadelphia, W.B. Saunders. 1976. pp: 923-9.
9. Henry JB. Clinical Diagnosis and Management by Laboratory Methods. Philadelphia, W.B. Saunders. 1984. pp:1434
10. Asagba SO, Eriyamremu, GE, George, BO, Okoro I. Biochemical indices of severity in human malaria. J Med Sci. 2010;10(4):87-92. [DOI via Crossref]   
11. Djjaman J, Abouamou S, Basco L, Kone M. Limits of the efficacy of chloroquine and sulfadoxinepyrimethamine in northern Abidjan (Cote d'Ivoire): combined in vivo and in vitro studies. Sante. 2004;14(4):205-9.
12. Muller S, Kappes B. Vitamin and co-factor biosynthesis pathways in Plasmodium and other apicomplexan parasites. Trend Parasitol. 2007;23(3):112-21. [DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   

How to Cite this Article
Pubmed Style

Onyesom Innocent, Osioma Ejovi, Edah Omosco Charles. Levels of iron and magnesium in serum of Plasmodium falciparum malarial infected children in Abraka, Delta State, Nigeria. A J Physiol Biochem Pharmacol. 2013; 2(1): 62-64. doi:10.5455/jib.20121006081938


Web Style

Onyesom Innocent, Osioma Ejovi, Edah Omosco Charles. Levels of iron and magnesium in serum of Plasmodium falciparum malarial infected children in Abraka, Delta State, Nigeria. http://www.ajpbp.com/?mno=21377 [Access: November 18, 2018]. doi:10.5455/jib.20121006081938


AMA (American Medical Association) Style

Onyesom Innocent, Osioma Ejovi, Edah Omosco Charles. Levels of iron and magnesium in serum of Plasmodium falciparum malarial infected children in Abraka, Delta State, Nigeria. A J Physiol Biochem Pharmacol. 2013; 2(1): 62-64. doi:10.5455/jib.20121006081938



Vancouver/ICMJE Style

Onyesom Innocent, Osioma Ejovi, Edah Omosco Charles. Levels of iron and magnesium in serum of Plasmodium falciparum malarial infected children in Abraka, Delta State, Nigeria. A J Physiol Biochem Pharmacol. (2013), [cited November 18, 2018]; 2(1): 62-64. doi:10.5455/jib.20121006081938



Harvard Style

Onyesom Innocent, Osioma Ejovi, Edah Omosco Charles (2013) Levels of iron and magnesium in serum of Plasmodium falciparum malarial infected children in Abraka, Delta State, Nigeria. A J Physiol Biochem Pharmacol, 2 (1), 62-64. doi:10.5455/jib.20121006081938



Turabian Style

Onyesom Innocent, Osioma Ejovi, Edah Omosco Charles. 2013. Levels of iron and magnesium in serum of Plasmodium falciparum malarial infected children in Abraka, Delta State, Nigeria. American Journal of Physiology, Biochemistry and Pharmacology, 2 (1), 62-64. doi:10.5455/jib.20121006081938



Chicago Style

Onyesom Innocent, Osioma Ejovi, Edah Omosco Charles. "Levels of iron and magnesium in serum of Plasmodium falciparum malarial infected children in Abraka, Delta State, Nigeria." American Journal of Physiology, Biochemistry and Pharmacology 2 (2013), 62-64. doi:10.5455/jib.20121006081938



MLA (The Modern Language Association) Style

Onyesom Innocent, Osioma Ejovi, Edah Omosco Charles. "Levels of iron and magnesium in serum of Plasmodium falciparum malarial infected children in Abraka, Delta State, Nigeria." American Journal of Physiology, Biochemistry and Pharmacology 2.1 (2013), 62-64. Print. doi:10.5455/jib.20121006081938



APA (American Psychological Association) Style

Onyesom Innocent, Osioma Ejovi, Edah Omosco Charles (2013) Levels of iron and magnesium in serum of Plasmodium falciparum malarial infected children in Abraka, Delta State, Nigeria. American Journal of Physiology, Biochemistry and Pharmacology, 2 (1), 62-64. doi:10.5455/jib.20121006081938





Most Viewed Articles
  • Slippery Elm, its Biochemistry, and use as a Complementary and Alternative Treatment for Laryngeal Irritation
    Christopher R Watts, Bernard rousseau
    J Investig Biochem. 2012; 1(1): 17-23
    » Abstract & References » doi: 10.5455/jib.20120417052415

  • Selected disease fundamentals based on the unified cell bioenergetics
    Andrzej Kasperski, Renata Kasperska
    J Investig Biochem. 2013; 2(2): 93-100
    » Abstract & References » doi: 10.5455/jib.20130227041230

  • Prevalence of vitamin B12 deficiency in Helicobacter pylori infected patients in Jordan.
    Saad Abed Aljalil Alfawaeir, Mohammad Basim Abuzaid
    J Investig Biochem. 2013; 2(1): 21-25
    » Abstract & References » doi: 10.5455/jib.20121215061954

  • Serum levels of high-sensitivity C-reactive protein (hs-CRP) in Helicobacter pylori infected patients
    Saad Al-Fawaeir, Mohammad Basim Abu Zaid
    J Investig Biochem. 2013; 2(1): 32-36
    » Abstract & References » doi: 10.5455/jib.20121225015606

  • Molecular Characterization of Alpha and Beta Thalassemia in Yemeni Sickle Cell Disease Children
    Saeed Thabet Nasher, Mohammed Wael Abu Ghoush
    J Investig Biochem. 2013; 2(1): 44-52
    » Abstract & References » doi: 10.5455/jib.20130105022014

  • Hepatoprotective and In vivo Anti-oxidant Activity of Costus afer Leaf Extracts against Acetaminophen-Induced Hepatotoxicity in Rats
    God'swill Nduka Anyasor, Kofoworola O. Odunsanya, Audrey C. Ibeneme
    J Investig Biochem. 2013; 2(1): 53-61
    » Abstract & References » doi: 10.5455/jib.20130301030851

  • Correlation Between Elevated Hepatic Enzymes & High-Sensitivity Crp in Metabolic Syndrome.
    Al-Rubaye Faisal, Shakir Mahmood, Jumah Kadhum
    J Investig Biochem. 2012; 1(1): 6-11
    » Abstract & References » doi: 10.5455/jib.20120528094732

  • Serum Lipid Profile of Breast Cancer Patients in Kashmir
    Showkat Ahmad Bhat, Manzoor R Mir, Sabhiya Majid, Ahmad Arif Reshi, Ishraq Husain, Tehseen Hassan, Hilal Ahmad
    J Investig Biochem. 2013; 2(1): 26-31
    » Abstract & References » doi: 10.5455/jib.20121125075314

  • Alteration of antioxidant enzymes and oxidative stress in elderly patient.
    Seema L. Jawalekar1, Anil K. Bhutey2, Aarti Karnik3, Vasant T. Surve4
    J Investig Biochem. 2013; 2(1): 37-43
    » Abstract & References » doi: 10.5455/jib.20130129093838

  • Potential Role of Oxidized LDL (ox-LDL) and Adhesion Molecules (VCAM-1, ICAM-1) in Type 2 Diabetes Mellitus Patients in Qassim region, KSA
    Manal Basyouni, Maha Ahmed, Hisham Ismail , Iman Esmat
    J Investig Biochem. 2012; 1(1): 48-54
    » Abstract & References » doi: 10.5455/jib.20120417052458

  • Most Downloaded
  • Slippery Elm, its Biochemistry, and use as a Complementary and Alternative Treatment for Laryngeal Irritation
    Christopher R Watts, Bernard rousseau
    J Investig Biochem. 2012; 1(1): 17-23
    » Abstract & References » doi: 10.5455/jib.20120417052415

  • Selected disease fundamentals based on the unified cell bioenergetics
    Andrzej Kasperski, Renata Kasperska
    J Investig Biochem. 2013; 2(2): 93-100
    » Abstract & References » doi: 10.5455/jib.20130227041230

  • Serum levels of high-sensitivity C-reactive protein (hs-CRP) in Helicobacter pylori infected patients
    Saad Al-Fawaeir, Mohammad Basim Abu Zaid
    J Investig Biochem. 2013; 2(1): 32-36
    » Abstract & References » doi: 10.5455/jib.20121225015606

  • Alteration of antioxidant enzymes and oxidative stress in elderly patient.
    Seema L. Jawalekar1, Anil K. Bhutey2, Aarti Karnik3, Vasant T. Surve4
    J Investig Biochem. 2013; 2(1): 37-43
    » Abstract & References » doi: 10.5455/jib.20130129093838

  • Serum Lipid Profile of Breast Cancer Patients in Kashmir
    Showkat Ahmad Bhat, Manzoor R Mir, Sabhiya Majid, Ahmad Arif Reshi, Ishraq Husain, Tehseen Hassan, Hilal Ahmad
    J Investig Biochem. 2013; 2(1): 26-31
    » Abstract & References » doi: 10.5455/jib.20121125075314

  • Hepatoprotective and In vivo Anti-oxidant Activity of Costus afer Leaf Extracts against Acetaminophen-Induced Hepatotoxicity in Rats
    God'swill Nduka Anyasor, Kofoworola O. Odunsanya, Audrey C. Ibeneme
    J Investig Biochem. 2013; 2(1): 53-61
    » Abstract & References » doi: 10.5455/jib.20130301030851

  • Evaluation of glycated albumin and microalbuminuria as early risk markers of nephropathy in type 2 diabetes mellitus
    Suresh Babu Kondaveeti, Ivvala Anand Shaker
    J Investig Biochem. 2013; 2(2): 127-131
    » Abstract & References » doi: 10.5455/jib.20130507061739

  • Comparative study of ischemia modified albumin and nitric oxide in hyperthyroidism
    Monica Verma1, Kiran Dahiya1, Veena Singh Ghalaut1, Abhishek Soni2, Jagjeet Singh3, Vasudha Dhupper1
    J Investig Biochem. 2014; 3(1): 17-20
    » Abstract & References » doi: 10.5455/jib.20130707090209

  • Prevalence of vitamin B12 deficiency in Helicobacter pylori infected patients in Jordan.
    Saad Abed Aljalil Alfawaeir, Mohammad Basim Abuzaid
    J Investig Biochem. 2013; 2(1): 21-25
    » Abstract & References » doi: 10.5455/jib.20121215061954

  • Serum lipid profile in Helicobacter pylori infected patients
    Saad Al-Fawaeir, Mohammad Abu Zaid, Ayman Abu Awad, Baker Alabedallat
    J Investig Biochem. 2013; 2(2): 132-135
    » Abstract & References » doi: 10.5455/jib.20130603084538

  • Most Cited Articles
  • Biochemical study on the impact of Nigella sativa and virgin olive oils on cadmium-induced nephrotoxicity and neurotoxicity in rats
    Eman Taha Mohammed, Khalid Shaban Hashem, Mahmoud Ramadan Abdel Rheim
    J Investig Biochem. 2014; 3(2): 71-78
    » Abstract & References » doi: 10.5455/jib.20140716041908
    Cited : 6 times [Click to see citing articles]

  • Study and Characterization of the Antioxidant Activity of the Inclusion Complex of Apigenin with β-Cyclodextrin and HP-β-Cyclodextrin in solution
    Jinxia Li
    J Investig Biochem. 2014; 3(3): 107-111
    » Abstract & References » doi: 10.5455/jib.20140905032504
    Cited : 5 times [Click to see citing articles]

  • Slippery Elm, its Biochemistry, and use as a Complementary and Alternative Treatment for Laryngeal Irritation
    Christopher R Watts, Bernard rousseau
    J Investig Biochem. 2012; 1(1): 17-23
    » Abstract & References » doi: 10.5455/jib.20120417052415
    Cited : 4 times [Click to see citing articles]

  • Alterations in plasma lipids, glutathione and homocysteine in relation to dietary copper in rats
    Magda A. Megahed1, Kamel M. A. Hassanin2, Ibrahim M. I. Youssef3, Abdul Baset A. Elfghi4, Kamal A. Amin2
    J Investig Biochem. 2014; 3(1): 21-25
    » Abstract & References » doi: 10.5455/jib.20130716075753
    Cited : 4 times [Click to see citing articles]

  • Quercetin, a natural phytochemical and antioxidant protects against sodium azide-induced hepatic and splenic oxidative stress in rats
    Oluwatobi Temitope Somade, Oluseyi Adeboye Akinloye, Michael Oluwayemi Adeyeye, Gbenga Daniel Fabunmi, Olakunle Opeoluwa Idowu, Funmilayo Oluwaseun Badmus, Barakat Oluwatoyin Salaudeen
    J Investig Biochem. 2015; 4(3): 69-74
    » Abstract & References » doi: 10.5455/jib.20151220014400
    Cited : 3 times [Click to see citing articles]

  • A New Marker For The Diagnosýs Of Sepsis: Presepsin
    Mehmet Agilli, Irfan Sener, Fatih Yesildal, Tevfik Honca, Ibrahim Aydin, Emin Ozgur Akgul, Halil Yaman
    J Investig Biochem. 2012; 1(1): 55-57
    » Abstract & References » doi: 10.5455/jib.20120521073837
    Cited : 3 times [Click to see citing articles]

  • The role of urinary 5- hydroxyindoleacetic acid determination in diagnosis of acute appendicitis
    Hamid Hindi Sarhan, Aseel Fawzi Hatroosh, Amina Hamed Alobaidi
    J Investig Biochem. 2013; 2(1): 1-5
    » Abstract & References » doi: 10.5455/jib.20121026084836
    Cited : 3 times [Click to see citing articles]

  • Serum Lipid Profile of Breast Cancer Patients in Kashmir
    Showkat Ahmad Bhat, Manzoor R Mir, Sabhiya Majid, Ahmad Arif Reshi, Ishraq Husain, Tehseen Hassan, Hilal Ahmad
    J Investig Biochem. 2013; 2(1): 26-31
    » Abstract & References » doi: 10.5455/jib.20121125075314
    Cited : 3 times [Click to see citing articles]

  • Phytochemical content of Cnidoscolus aconitifolius leaves and toxicological effect of its aqueous leaf extract in Wistar rats
    Doris Akachukwu, Polycarp Nnacheta Okafor, Chiedozie O Ibegbulem
    J Investig Biochem. 2014; 3(1): 26-31
    » Abstract & References » doi: 10.5455/jib.20140504023102
    Cited : 3 times [Click to see citing articles]

  • Myeloperoxidase, Malondialdehyde and serum Lipids in type 2 diabetes mellitus
    Mohamedi Begum, Ashok Kumar J., Hilda Priya D'Souza, Sushith Sushith, Prathima M.B, Reshma S., Shashikala M.D, Manjula Anil, Suriyan S Nair, Kavitha Ashok Kumar
    J Investig Biochem. 2015; 4(1): 13-17
    » Abstract & References » doi: 10.5455/jib.20150331115356
    Cited : 3 times [Click to see citing articles]