E-ISSN 2578-7322
 

Original Research 


EVALUATION OF THE EFFECT OF ANTI-TOXOPLASMIC DRUGS ON THE BIODISTRIBUTION OF THE RADIOPHARMACEUTICAL SODIUM PERTECHNETATE

Ranny Beatriz de Carvalho Holanda Leite, João Cláudio da Costa Urbano, Renan Leopoldo Pereira Castro, Clarice Maux Vianna da Silva, Aldo da Cunha Medeiros, Ítalo Medeiros de Azevêdo, Vanessa Santos de Arruda Barbosa, Cecília Maria de Carvalho Xavier Holanda.

Abstract
The human toxoplasmosis is a disease caused by the parasite Toxoplasma gondii that can affect the growing baby in pregnancy and it is the most common CNS infection in patients with AIDS. Its treatment is made by the synergistic association of the drugs pyrimethamine (PM) and sulfadiazine (SDZ). Objective: the aim of this study was to evaluate if the use of the combination of PM and SDZ changes the sodium pertechnetate (Na99mTcO4-) biodistribution in non-infected animals by the T. gondii. It was used 24 male Swiss mice equally divided into 4 groups: 1 control group and 3 treated groups. Methods: the control group received 0.5 mL of distilled water; the treated group 1 received 0.5 mL of a PM solution; the treated group 2 received 0.5 mL of a SDZ solution and the treated group 3 received 0.5 mL of the PM+SDZ, all by the gavage method for 10 days. On the 10th day and 1 h after the last dose, all groups received 0.1mL of Na99mTcO4- (0.66MBq) via the femoral vein. After 40 min, the animals were euthanized, and blood and brain samples were isolated. The percentage of total activity injected per gram of organ (%ATI/g) was calculated on the gamma counter. Statistical analysis were performed using the T-test, considering a level of significance of p<0.05. Results: there was a statistically significant increase in %ATI/g in the blood, from the control group to the treated group with PM+SDZ (from 2.53±0.17 to 4.53±0.31) and also in the brain (from 0.09±0.01 to 0.19±0.04). There was no statistically significant difference between the control group and those treated alone with PM and SDZ. Conclusions: it can be concluded that both the drugs used alone and in combination do not interfere in the biodistribution of the radiopharmaceutical in nuclear medicine exams.

Key words: Anti-Toxoplasma drugs. Synergistic drugs. Sodium pertechnetate. Toxoplasma gondii. Sulfadiazine. Pyrimethamine.


 
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Pubmed Style

Ranny Beatriz de Carvalho Holanda Leite, João Cláudio da Costa Urbano, Renan Leopoldo Pereira Castro, Clarice Maux Vianna da Silva, Aldo da Cunha Medeiros, Ítalo Medeiros de Azevêdo, Vanessa Santos de Arruda Barbosa, Cecília Maria de Carvalho Xavier Holanda. EVALUATION OF THE EFFECT OF ANTI-TOXOPLASMIC DRUGS ON THE BIODISTRIBUTION OF THE RADIOPHARMACEUTICAL SODIUM PERTECHNETATE. A J Physiol Biochem Pharmacol. 2018; 8(1): 28-33. doi:10.5455/ajpbp.20180624014448


Web Style

Ranny Beatriz de Carvalho Holanda Leite, João Cláudio da Costa Urbano, Renan Leopoldo Pereira Castro, Clarice Maux Vianna da Silva, Aldo da Cunha Medeiros, Ítalo Medeiros de Azevêdo, Vanessa Santos de Arruda Barbosa, Cecília Maria de Carvalho Xavier Holanda. EVALUATION OF THE EFFECT OF ANTI-TOXOPLASMIC DRUGS ON THE BIODISTRIBUTION OF THE RADIOPHARMACEUTICAL SODIUM PERTECHNETATE. http://www.ajpbp.com/?mno=302627 [Access: November 18, 2018]. doi:10.5455/ajpbp.20180624014448


AMA (American Medical Association) Style

Ranny Beatriz de Carvalho Holanda Leite, João Cláudio da Costa Urbano, Renan Leopoldo Pereira Castro, Clarice Maux Vianna da Silva, Aldo da Cunha Medeiros, Ítalo Medeiros de Azevêdo, Vanessa Santos de Arruda Barbosa, Cecília Maria de Carvalho Xavier Holanda. EVALUATION OF THE EFFECT OF ANTI-TOXOPLASMIC DRUGS ON THE BIODISTRIBUTION OF THE RADIOPHARMACEUTICAL SODIUM PERTECHNETATE. A J Physiol Biochem Pharmacol. 2018; 8(1): 28-33. doi:10.5455/ajpbp.20180624014448



Vancouver/ICMJE Style

Ranny Beatriz de Carvalho Holanda Leite, João Cláudio da Costa Urbano, Renan Leopoldo Pereira Castro, Clarice Maux Vianna da Silva, Aldo da Cunha Medeiros, Ítalo Medeiros de Azevêdo, Vanessa Santos de Arruda Barbosa, Cecília Maria de Carvalho Xavier Holanda. EVALUATION OF THE EFFECT OF ANTI-TOXOPLASMIC DRUGS ON THE BIODISTRIBUTION OF THE RADIOPHARMACEUTICAL SODIUM PERTECHNETATE. A J Physiol Biochem Pharmacol. (2018), [cited November 18, 2018]; 8(1): 28-33. doi:10.5455/ajpbp.20180624014448



Harvard Style

Ranny Beatriz de Carvalho Holanda Leite, João Cláudio da Costa Urbano, Renan Leopoldo Pereira Castro, Clarice Maux Vianna da Silva, Aldo da Cunha Medeiros, Ítalo Medeiros de Azevêdo, Vanessa Santos de Arruda Barbosa, Cecília Maria de Carvalho Xavier Holanda (2018) EVALUATION OF THE EFFECT OF ANTI-TOXOPLASMIC DRUGS ON THE BIODISTRIBUTION OF THE RADIOPHARMACEUTICAL SODIUM PERTECHNETATE. A J Physiol Biochem Pharmacol, 8 (1), 28-33. doi:10.5455/ajpbp.20180624014448



Turabian Style

Ranny Beatriz de Carvalho Holanda Leite, João Cláudio da Costa Urbano, Renan Leopoldo Pereira Castro, Clarice Maux Vianna da Silva, Aldo da Cunha Medeiros, Ítalo Medeiros de Azevêdo, Vanessa Santos de Arruda Barbosa, Cecília Maria de Carvalho Xavier Holanda. 2018. EVALUATION OF THE EFFECT OF ANTI-TOXOPLASMIC DRUGS ON THE BIODISTRIBUTION OF THE RADIOPHARMACEUTICAL SODIUM PERTECHNETATE. American Journal of Physiology, Biochemistry and Pharmacology, 8 (1), 28-33. doi:10.5455/ajpbp.20180624014448



Chicago Style

Ranny Beatriz de Carvalho Holanda Leite, João Cláudio da Costa Urbano, Renan Leopoldo Pereira Castro, Clarice Maux Vianna da Silva, Aldo da Cunha Medeiros, Ítalo Medeiros de Azevêdo, Vanessa Santos de Arruda Barbosa, Cecília Maria de Carvalho Xavier Holanda. "EVALUATION OF THE EFFECT OF ANTI-TOXOPLASMIC DRUGS ON THE BIODISTRIBUTION OF THE RADIOPHARMACEUTICAL SODIUM PERTECHNETATE." American Journal of Physiology, Biochemistry and Pharmacology 8 (2018), 28-33. doi:10.5455/ajpbp.20180624014448



MLA (The Modern Language Association) Style

Ranny Beatriz de Carvalho Holanda Leite, João Cláudio da Costa Urbano, Renan Leopoldo Pereira Castro, Clarice Maux Vianna da Silva, Aldo da Cunha Medeiros, Ítalo Medeiros de Azevêdo, Vanessa Santos de Arruda Barbosa, Cecília Maria de Carvalho Xavier Holanda. "EVALUATION OF THE EFFECT OF ANTI-TOXOPLASMIC DRUGS ON THE BIODISTRIBUTION OF THE RADIOPHARMACEUTICAL SODIUM PERTECHNETATE." American Journal of Physiology, Biochemistry and Pharmacology 8.1 (2018), 28-33. Print. doi:10.5455/ajpbp.20180624014448



APA (American Psychological Association) Style

Ranny Beatriz de Carvalho Holanda Leite, João Cláudio da Costa Urbano, Renan Leopoldo Pereira Castro, Clarice Maux Vianna da Silva, Aldo da Cunha Medeiros, Ítalo Medeiros de Azevêdo, Vanessa Santos de Arruda Barbosa, Cecília Maria de Carvalho Xavier Holanda (2018) EVALUATION OF THE EFFECT OF ANTI-TOXOPLASMIC DRUGS ON THE BIODISTRIBUTION OF THE RADIOPHARMACEUTICAL SODIUM PERTECHNETATE. American Journal of Physiology, Biochemistry and Pharmacology, 8 (1), 28-33. doi:10.5455/ajpbp.20180624014448





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