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Hepatoprotective and In vivo Anti-oxidant Activity of Costus afer Leaf Extracts against Acetaminophen-Induced Hepatotoxicity in Rats

God'swill Nduka Anyasor, Kofoworola O. Odunsanya, Audrey C. Ibeneme.

Cited by (1)

Abstract
This study investigated the hepatoprotective and in vivo antioxidant activity of orally administered chloroform and ethanol Costus afer leaf extracts (20 - 60 mg/kg b.w.) on 1 g/kg b.w. acetaminophen-induced acute hepatic injury in albino rats for 7 days. Result showed no significant difference in plasma and hepatic superoxide activities. Plasma catalase (CAT) activity was significantly reduced in 20 and 40 mg/kg chloroform extracts and 20 mg/kg ethanol extract treated groups. Hepatic CAT activity was reduced significantly at co-administered 20 mg/kg ethanol extract and 1 g/kg ACT treated group. Plasma and hepatic glutathione levels were elevated significantly in chloroform and ethanol leaf extracts treated groups. The plasma and liver glutathione S-transferase activity in the chloroform extract groups were significantly reduced while ethanol leaf extract showed no significant difference. The plasma and hepatic MDA concentrations in the chloroform and ethanol extracts treated groups were found reduced. Further studies showed that the reduction in AST and ALT elevated activities induced by ACT was more profound in ethanol treated groups than chloroform treated groups. Therefore, findings from this present study indicate that the chloroform leaf extract possess high antioxidant effect than ethanol leaf extracts while ethanol leaf extract possess high hepatoprotective potentials than chloroform leaf extract.

Key words: Antioxidant, acetaminophen, Costus afer, hepatoprotective


 
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How to Cite this Article
Pubmed Style

God\swill Nduka Anyasor, Kofoworola O. Odunsanya, Audrey C. Ibeneme. Hepatoprotective and In vivo Anti-oxidant Activity of Costus afer Leaf Extracts against Acetaminophen-Induced Hepatotoxicity in Rats. A J Physiol Biochem Pharmacol. 2013; 2(1): 53-61. doi:10.5455/jib.20130301030851


Web Style

God\swill Nduka Anyasor, Kofoworola O. Odunsanya, Audrey C. Ibeneme. Hepatoprotective and In vivo Anti-oxidant Activity of Costus afer Leaf Extracts against Acetaminophen-Induced Hepatotoxicity in Rats. http://www.ajpbp.com/?mno=32189 [Access: November 18, 2018]. doi:10.5455/jib.20130301030851


AMA (American Medical Association) Style

God\swill Nduka Anyasor, Kofoworola O. Odunsanya, Audrey C. Ibeneme. Hepatoprotective and In vivo Anti-oxidant Activity of Costus afer Leaf Extracts against Acetaminophen-Induced Hepatotoxicity in Rats. A J Physiol Biochem Pharmacol. 2013; 2(1): 53-61. doi:10.5455/jib.20130301030851



Vancouver/ICMJE Style

God\swill Nduka Anyasor, Kofoworola O. Odunsanya, Audrey C. Ibeneme. Hepatoprotective and In vivo Anti-oxidant Activity of Costus afer Leaf Extracts against Acetaminophen-Induced Hepatotoxicity in Rats. A J Physiol Biochem Pharmacol. (2013), [cited November 18, 2018]; 2(1): 53-61. doi:10.5455/jib.20130301030851



Harvard Style

God\swill Nduka Anyasor, Kofoworola O. Odunsanya, Audrey C. Ibeneme (2013) Hepatoprotective and In vivo Anti-oxidant Activity of Costus afer Leaf Extracts against Acetaminophen-Induced Hepatotoxicity in Rats. A J Physiol Biochem Pharmacol, 2 (1), 53-61. doi:10.5455/jib.20130301030851



Turabian Style

God\swill Nduka Anyasor, Kofoworola O. Odunsanya, Audrey C. Ibeneme. 2013. Hepatoprotective and In vivo Anti-oxidant Activity of Costus afer Leaf Extracts against Acetaminophen-Induced Hepatotoxicity in Rats. American Journal of Physiology, Biochemistry and Pharmacology, 2 (1), 53-61. doi:10.5455/jib.20130301030851



Chicago Style

God\swill Nduka Anyasor, Kofoworola O. Odunsanya, Audrey C. Ibeneme. "Hepatoprotective and In vivo Anti-oxidant Activity of Costus afer Leaf Extracts against Acetaminophen-Induced Hepatotoxicity in Rats." American Journal of Physiology, Biochemistry and Pharmacology 2 (2013), 53-61. doi:10.5455/jib.20130301030851



MLA (The Modern Language Association) Style

God\swill Nduka Anyasor, Kofoworola O. Odunsanya, Audrey C. Ibeneme. "Hepatoprotective and In vivo Anti-oxidant Activity of Costus afer Leaf Extracts against Acetaminophen-Induced Hepatotoxicity in Rats." American Journal of Physiology, Biochemistry and Pharmacology 2.1 (2013), 53-61. Print. doi:10.5455/jib.20130301030851



APA (American Psychological Association) Style

God\swill Nduka Anyasor, Kofoworola O. Odunsanya, Audrey C. Ibeneme (2013) Hepatoprotective and In vivo Anti-oxidant Activity of Costus afer Leaf Extracts against Acetaminophen-Induced Hepatotoxicity in Rats. American Journal of Physiology, Biochemistry and Pharmacology, 2 (1), 53-61. doi:10.5455/jib.20130301030851





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