E-ISSN 2578-7322
 

Original Research 


Effect of lactoferrin on some selective immunological parameters in rats immunosuppressed by cyclophosphamide

Osama Ali Abdalla, Mohamed El-Sayed El-Boshy.

Abstract
Eighty male albino rats (350±10 g) 10 to 12 weeks old were conducted in our study. Rats were randomly divided into four, equal groups. The groups treated as following: 1st control group (Gp. A) was given intraperitoneal normal saline (1 mL). 2nd group (Gp. B) was given a single intraperitoneal dose (250 mg/kg body weight) of Cyclophosphamide (CP) on the first day of the experimental period. 3rd group (Gp. C) CP and lactoferrin (LF) treated group. 4th group (Gp. D) administrated LF only (0.5%) in drinking water. Two separate blood samples were collected from heart puncture at end of 1st and 3rd week post treatment for hematological, biochemical and immunological studies. The leukogram of CP treatment group showed severe leucopenia (lymphopenia, neutropenia as well as eozinopenia) as well as decrease total protein and albumin blood level. Immunosuppressive effect of CP is documented in our work by decrease gamma globulin and elevation tumor necrosis factor Alfa (TNF ά). This study revealed that oral treatment with LF can partially

Key words: Lactoferrin; immunomodulatory; cyclophosphamide.


 
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How to Cite this Article
Pubmed Style

Osama Ali Abdalla, Mohamed El-Sayed El-Boshy. Effect of lactoferrin on some selective immunological parameters in rats immunosuppressed by cyclophosphamide. A J Physiol Biochem Pharmacol. 2013; 2(2): 136-140. doi:10.5455/jib.20130606110934


Web Style

Osama Ali Abdalla, Mohamed El-Sayed El-Boshy. Effect of lactoferrin on some selective immunological parameters in rats immunosuppressed by cyclophosphamide. http://www.ajpbp.com/?mno=37078 [Access: November 18, 2018]. doi:10.5455/jib.20130606110934


AMA (American Medical Association) Style

Osama Ali Abdalla, Mohamed El-Sayed El-Boshy. Effect of lactoferrin on some selective immunological parameters in rats immunosuppressed by cyclophosphamide. A J Physiol Biochem Pharmacol. 2013; 2(2): 136-140. doi:10.5455/jib.20130606110934



Vancouver/ICMJE Style

Osama Ali Abdalla, Mohamed El-Sayed El-Boshy. Effect of lactoferrin on some selective immunological parameters in rats immunosuppressed by cyclophosphamide. A J Physiol Biochem Pharmacol. (2013), [cited November 18, 2018]; 2(2): 136-140. doi:10.5455/jib.20130606110934



Harvard Style

Osama Ali Abdalla, Mohamed El-Sayed El-Boshy (2013) Effect of lactoferrin on some selective immunological parameters in rats immunosuppressed by cyclophosphamide. A J Physiol Biochem Pharmacol, 2 (2), 136-140. doi:10.5455/jib.20130606110934



Turabian Style

Osama Ali Abdalla, Mohamed El-Sayed El-Boshy. 2013. Effect of lactoferrin on some selective immunological parameters in rats immunosuppressed by cyclophosphamide. American Journal of Physiology, Biochemistry and Pharmacology, 2 (2), 136-140. doi:10.5455/jib.20130606110934



Chicago Style

Osama Ali Abdalla, Mohamed El-Sayed El-Boshy. "Effect of lactoferrin on some selective immunological parameters in rats immunosuppressed by cyclophosphamide." American Journal of Physiology, Biochemistry and Pharmacology 2 (2013), 136-140. doi:10.5455/jib.20130606110934



MLA (The Modern Language Association) Style

Osama Ali Abdalla, Mohamed El-Sayed El-Boshy. "Effect of lactoferrin on some selective immunological parameters in rats immunosuppressed by cyclophosphamide." American Journal of Physiology, Biochemistry and Pharmacology 2.2 (2013), 136-140. Print. doi:10.5455/jib.20130606110934



APA (American Psychological Association) Style

Osama Ali Abdalla, Mohamed El-Sayed El-Boshy (2013) Effect of lactoferrin on some selective immunological parameters in rats immunosuppressed by cyclophosphamide. American Journal of Physiology, Biochemistry and Pharmacology, 2 (2), 136-140. doi:10.5455/jib.20130606110934





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