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Comparison of rheumatoid factor of IgM, IgG and IgA isotypes with disease activity score 28 in patients of rheumatoid arthritis

Sana Zainab, Muhammad Kashif, Romeeza Tahir, Faheem Shahzad, Aflak Rasheed, Waqas Latif, Tafazzul H Mahmud, Nadeem Afzal.

Abstract
Introduction/background: Rheumatoid factor (RF) is a widely used serological marker for the diagnosis of rheumatoid arthriris (RA). RF can be detected in up to 70 to 80% of RA patients and it is associated with disease activity, bone erosion, and disease outcome. RF is an autoantibody targeting the 'fraction crystallizable' (Fc) region of IgG antibodies and exists as IgA, IgG and IgM isotypes. The objective of this study was to compare the RF isotypes IgM, IgG and IgA with disease activity score 28 in rheumatoid arthritis patients.
Materials and Methods: This was a descriptive study, which included 83 RA patients. Blood samples of the patients were collected from the Department of Rheumatology, Sheikh Zayed Hospital Lahore. The levels of different isotypes of RF i.e. IgM, IgG and IgA were determined by ELISA technique. Data was analysed by SPSS 20.0.
Results: RF, IgM, IgG, and IgA isotype, was detected in 83%, 10%, and 40% of RA patients respectively. RF istoypes were compared with DAS28. There was no significant association between DAS 28 and RF IgM [Odd ratio (CI)] [0.5(0.07-3.18)], RF IgG [3.0(0.27-32.20)] and RF IgA [0.4(0.43-0.13)]. Disease duration was also compared with RF isotypes but no significant association found. There was no significant association between disease duration and RF IgM [Odd ratio (CI)] [1.4(0.46-4.86)], RF IgG [1.6(0.50-5.0)] and RF IgA [1.1(0.53-2.7)]. Conclusion: All the isotypes of RF were detected in RA patients. As a screening method for rheumatoid arthritis the IgM-RF is superior to other RF isotypes. RF titer may be valueable in estimation of disease activity and other inflammatory parameters in RA patients.

Key words: Rheumatoid arthritis; Rheumatoid factor; DAS28; RF isotypes


 
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REFERENCES
1. Norton JA, Thom AK. Parenteral nutrition and the patient with cancer. In:Rombeau JL. Clininal nutrition, parenteral nutrition (2nd ed.) Philadelphia, WB Saunders Com, 1993; 512-37.
2. Gianotti L. Cerrahide beslenme desteði. In: Sayek Ý. Temel Cerrahi (3. Baský). Ankara, Güneþ Kitapevi. 2004; 125-136.
3. Bistrian BR, Blackburn GL, Vitale J, Cochran D, Naylor J. Prevalence of malnutrition in general medical patients. JAMA 1976;235(15):1567-70. [DOI via Crossref]    [Pubmed]   
4. Hill GL, Blackett RL, Pickford I, Burkinshaw L, Young GA, Warren JV, et al. Malnutrition in surgical patients. An unrecognised problem. Lancet 1977;1(8013):689-92. [DOI via Crossref]   
5. Gündoðdu H. Cerrahi hastada beslenme desteði. Cerrahi Týp Bilimleri Derg 2000;3:3-21.
6. Buzby GP, Mullen JL, Matthews DC, Hobbs CL, Rosato EF. Rognostic nutritional index in gastrointestinal surgery. Am J Surg 1980;139(1):160-7. [DOI via Crossref]   
7. Palesty JA, Dudrick SJ. What we have learned about cachexia in gastrointestinal cancer. Dig Dis 2003;21(3):198-213. [DOI via Crossref]   
8. Holter AR, Fischer JE. The effects of perioperative hyperalimentation on complications in patients with carcinoma and weight loss. J Surg Res 1977;23(1):31-4. [DOI via Crossref]   
9. Heatley RV, Williams RH, Lewis MH. Preoperative intravenous feeding. A controlled trial. Postgrad Med J 1979;55(646):541-5. [DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   
10. Thompson BR, Julian TB, Stemple JF. Perioperative total parenteral nutrition in patients with gastrointestinal cancer. J Surg Res 1981;30(5):497-500. [DOI via Crossref]   
11. Müller JM, Brenner U, Dienst C, Pichlmaier H. Preoperative parenteral feeding in patients with gastrointestinal carcinoma. Lancet 1982;1(8263):68-71. [DOI via Crossref]   
12. The Veterans affairs total parenteral nutrition cooperative study group. Perioperative total parenteral nutrition in surgical patients. N Eng J Med 1991;325(8):525-32. [DOI via Crossref]    [Pubmed]   
13. Dempsey DT, Mullen JL, Buzby GP. The link between nutritional status and clinical outcome: can nutritional intervention modify it? Am J Clin Nutr 1988;47(2 Suppl):352-6. [Pubmed]   
14. Ockenga J, Pirlich M, Gastell S, Lochs H. Tumour anorexia-tumour cachexia in case of gastrointestinal tumours: standards and vision. Z Gastroentorol 2002;40(11):929-36. [DOI via Crossref]    [Pubmed]   
15. Detsky AS, McLaughlin JR, Baker JP, Johnston N, Whittaker S, Mendelson RA, et al. What is subjective global assessment of nutritional status. JPEN J Parenter Enteral Nutr 1987;11(1):8-13. [DOI via Crossref]    [Pubmed]   
16. Sungurtekin H, Sungurtekin M, Hancý V, Erdem E. Comparison of two nutrition assessment techniques in hospitalized patients. Nutrition 2004;20(5):428-32. [DOI via Crossref]    [Pubmed]   
17. Gupta D, Lis CG, Vashi PG, Grutsch JF, Burrows J, Becker J, et al. The subjective global assessment (SGA) as a prognostic indicator in patients with advanced colorectal cancer. Proc Am Soc Clin Oncol 2003; 22: (abstr 1204).
18. Ulander K, Lundgren PO, Grahn G, Jeppsson B. Preoperative nutritional assessment of patients with colorectal cancer. Eur J Cancer 1995:31(Supplement 6):S276. [DOI via Crossref]   
19. Norman K, Schütz T, Kemps M, Josef Lübke H, Lochs H, Pirlich M. The subjective global assessment reliably identifies malnutrition-related muscle dysfunction. Clin Nutr 2005;24(1):143-50. [DOI via Crossref]    [Pubmed]   
20. Kuyumcu A, Polat-Düzgün A, Uzun S, Özmen MM, Coþkun F, Besler HT. Major abdominal cerrahi geçiren hastalarda preoperatif nutrisyonel deðerlendirme: ileri yaþ radikal cerrahiye engel midir? Türk Geriatri Dergisi 2003;6(4):128-34.
21. Jeejeebhoy KN. Total parenteral nutrition: potion or poison? Am J Clin Nutr 2001;74(2):160-3. [Pubmed]   
22. Iapichino G, Rossi C, Radrizzani D, Simini B, Albicini M, Ferla L, et al. Nutrition given to critically ill patients during high level/complex care (on Italian ICUs). Clin Nutr 2004;23(3):409-16. [DOI via Crossref]    [Pubmed]   
23. Dudrick SJ, Copeland EM, MacFadyen BV. Parenteral nutrition as an adjunct to cancer therapy. Klin Anasth Intensivmed 1977;13:1-12.
24. Bozetti F. Perioperatif nutrition of patients with gastrointestinal cancer. Br J Surg 2002;89(10):1201-2. [DOI via Crossref]    [Pubmed]   
25. Braga M, Gianotti L, Nespoli L, Radaelli G, Di Carlo V. Nutritional approach in malnourished surgical patients: a prospective randomized study. Arch Surg 2002;137(2):174-80. [DOI via Crossref]    [Pubmed]   
26. Hill GL, King RF, Smith RC, Smith AH, Oxby CB, Sharafi A, et al. Multi-element analysis of the living body by neutron activation analysis-application to critically ill patients receiving intravenous nutrition. Br J Surg 1979;66(12):868-72. [DOI via Crossref]    [Pubmed]   
27. Blackburn GL. Hyperalimentation in the critically ill patient. Heart Lung 1979;8(1):67-70. [Pubmed]   
28. Bellantone R, Doglietto GB, Bossola M, Pacelli F, Negro F, Sofo L, et al. Preoperatif parenteral nutrition in the high risk surgical patient. JPEN J Parenter Enteral Nutr 1988;12(2):195-7. [DOI via Crossref]    [Pubmed]   
29. Heyland DK, Montalvo M, MacDonald S, Keefe L, Su XY, Drover JW. Total parenteral nutrition in the surgical patient: a meta-analysis. Can J Surg 2001;44(2):102-11. [Pubmed]   
30. Von Meyenfeldt MF, Meijerink WJ, Rouflart MM, Builmaassen MT, Soeters PB. Perioperative nutritional support: a randomised clinical trial. Clin Nutr 1992;11(4):180-6. [DOI via Crossref]   
31. van den Berg A, van Elburg RM, Westerbeek EA, Twisk JW, Fetter WP. Glutamine-enriched enteral nutrition in very-low-birth-weight infants and effects on feeding tolerance and infectious morbidity: a randomized controlled trial. Am J Clin Nutr 2005;81(6):1397-404. [Pubmed]   
32. Fuentes-Orozco C, Anaya-Prado R, González-Ojeda A, Arenas-Márquez H, Cabrera-Pivaral C, Cervantes-Guevara G, et al. L-alanyl-L-glutamine-supplemented parenteral nutrition improves infectious morbidity in secondary peritonitis. Clin Nutr 2004; 23(1):13-21. [DOI via Crossref]   

How to Cite this Article
Pubmed Style

Zainab S, Kashif M, Tahir R, Shahzad F, Rasheed A, Latif W, Mahmud TH, Afzal N, . Comparison of rheumatoid factor of IgM, IgG and IgA isotypes with disease activity score 28 in patients of rheumatoid arthritis. A J Physiol Biochem Pharmacol. 2019; 9(2): 33-37. doi:10.5455/ajpbp.20181025040015


Web Style

Zainab S, Kashif M, Tahir R, Shahzad F, Rasheed A, Latif W, Mahmud TH, Afzal N, . Comparison of rheumatoid factor of IgM, IgG and IgA isotypes with disease activity score 28 in patients of rheumatoid arthritis. http://www.ajpbp.com/?mno=9154 [Access: September 21, 2019]. doi:10.5455/ajpbp.20181025040015


AMA (American Medical Association) Style

Zainab S, Kashif M, Tahir R, Shahzad F, Rasheed A, Latif W, Mahmud TH, Afzal N, . Comparison of rheumatoid factor of IgM, IgG and IgA isotypes with disease activity score 28 in patients of rheumatoid arthritis. A J Physiol Biochem Pharmacol. 2019; 9(2): 33-37. doi:10.5455/ajpbp.20181025040015



Vancouver/ICMJE Style

Zainab S, Kashif M, Tahir R, Shahzad F, Rasheed A, Latif W, Mahmud TH, Afzal N, . Comparison of rheumatoid factor of IgM, IgG and IgA isotypes with disease activity score 28 in patients of rheumatoid arthritis. A J Physiol Biochem Pharmacol. (2019), [cited September 21, 2019]; 9(2): 33-37. doi:10.5455/ajpbp.20181025040015



Harvard Style

Zainab, S. ., Kashif, M. ., Tahir, R. ., Shahzad, F. ., Rasheed, A. ., Latif, W. ., Mahmud, T. H., Afzal, N. . & (2019) Comparison of rheumatoid factor of IgM, IgG and IgA isotypes with disease activity score 28 in patients of rheumatoid arthritis. A J Physiol Biochem Pharmacol, 9 (2), 33-37. doi:10.5455/ajpbp.20181025040015



Turabian Style

Zainab, Sana , Muhammad Kashif, Romeeza Tahir, Faheem Shahzad, Aflak Rasheed, Waqas Latif, Tafazzul H Mahmud, Nadeem Afzal, and . 2019. Comparison of rheumatoid factor of IgM, IgG and IgA isotypes with disease activity score 28 in patients of rheumatoid arthritis. American Journal of Physiology, Biochemistry and Pharmacology, 9 (2), 33-37. doi:10.5455/ajpbp.20181025040015



Chicago Style

Zainab, Sana , Muhammad Kashif, Romeeza Tahir, Faheem Shahzad, Aflak Rasheed, Waqas Latif, Tafazzul H Mahmud, Nadeem Afzal, and . "Comparison of rheumatoid factor of IgM, IgG and IgA isotypes with disease activity score 28 in patients of rheumatoid arthritis." American Journal of Physiology, Biochemistry and Pharmacology 9 (2019), 33-37. doi:10.5455/ajpbp.20181025040015



MLA (The Modern Language Association) Style

Zainab, Sana , Muhammad Kashif, Romeeza Tahir, Faheem Shahzad, Aflak Rasheed, Waqas Latif, Tafazzul H Mahmud, Nadeem Afzal, and . "Comparison of rheumatoid factor of IgM, IgG and IgA isotypes with disease activity score 28 in patients of rheumatoid arthritis." American Journal of Physiology, Biochemistry and Pharmacology 9.2 (2019), 33-37. Print. doi:10.5455/ajpbp.20181025040015



APA (American Psychological Association) Style

Zainab, S. ., Kashif, M. ., Tahir, R. ., Shahzad, F. ., Rasheed, A. ., Latif, W. ., Mahmud, T. H., Afzal, N. . & (2019) Comparison of rheumatoid factor of IgM, IgG and IgA isotypes with disease activity score 28 in patients of rheumatoid arthritis. American Journal of Physiology, Biochemistry and Pharmacology, 9 (2), 33-37. doi:10.5455/ajpbp.20181025040015





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