Ameliorative effects of aqueous leaf extract of aloe arborescens on anti- hyperglycaemia and antihyperlipidemia alterations in alloxan-induced diabetic mice

Abstract

Bhaskar Sharma, Shiv Shanker Kumar, Sufiyan Siddiqui, Guru Dayal Ram, Manisha Chaudhary

Diabetes poses great challenge to the world’s health care system. Its worldwide prevalence was estimated at 366 million in 2011 of these, 183 million people were believed to be unaware of their condition. If no measures taken, the prevalence is projected to rise to 552 million people by 2030, representing around 10% of the global adult population. The aim of present study was designed to examine the potential anti-hyperlipidaemic and antihyperlipidemia efficacy of the aqueous extract from Aloe vera leaf gel in alloxan-induced diabetic mice. The animals were divided into three groups of normal mice; alloxan-induced diabetic mice and diabetic mice treated with 300mg/kg b.w of the aqueous leaf extract, respectively. Treatment was via the oral route for 21days. Various biochemical parameters, including lipid profile and serum glucose were decreased as well as HDL-C increased. Statistical analysis were done by one way analysis of variance (ANOVA) followed by Tukey’s multiple comparison test. These results demonstrate the anti-diabetic and antihyperlipidaemic activities of Aloe vera leaf extract in diabetic mice.