Assessment of ischemia modifi edalbumin in unstable angina and its correlation with selected acute phase reactants

Abstract

Neepa Chowdhury, Angshuman De, Rabindra Bhattacharya, Indranil Chakraborty, Sandip Chakraborty

Objective: There is evidence that ischemia modified albumin increases (IMA) in acute coronary syndrome but enough work has not been done in assessing the correlation between IMA and inflammatory markers in unstable angina (UA). The aim of the study was to observe whether IMA would significantly be altered in UA patients and also whether the same would be correlated with selected acute phase reactants. Method: The present hospital-based, non-interventional, cross-sectional study was undertaken in Medical College and Hospital, Kolkata. 47 cases of UA and 50 suitable controls were enrolled for the study. Serum IMA, serum albumin, serum total cholesterol, serum high-sensitivity C-reactive protein (hsCRP), serum ceruloplasmin and serum transferrin were measured in blood from the study population. Results: Serum IMA and hsCRP (P < 0.001) were significantly higher in UA cases whereas serum transferrin (P < 0.001) and albumin (P < 0.001) were significantly lower in cases as compared to controls. IMA was not correlated with acute phase reactants. Serum IMA (P − 0.06) was not considered as an important inflammatory marker in UA. However, serum hsCRP and serum transferrin play a significant role (P < 0.05) in assessing the severity of inflammation. Conclusions: Though there was a significant increase in IMA, but it was not correlated with common markers of inflammation in UA. IMA is not superior to other markers in identifying inflammation in UA.