Correlation between elevated hepatic enzymes & highsensitivity CRP in metabolic syndrome

Abstract

Faisal Gh. Al-Rubaye, Kadhum Jumah, Mahmood Shakir

BACKGROUND AND OBJECTIVES: The phrase "metabolic syndrome" was used to describe the joint incidence of hyperlipoproteinemia, diabetes, hypertension, gout and obesity in combination with an increased incidence of cardiovascular disease, fatty liver and cholelithiasis. Chronic, sub-clinical inflammation and its association with Metabolic Syndrome are well documented.. Fatty liver is now believed to be an integral part of the metabolic syndrome, since it has been shown to be independently related to insulin resistance independent of obesity and abdominal adiposity. AIM: to assess the status of high-sensitive C reactive protein and hepatic enzymes in patients’ with Metabolic Syndrome. METHODS: This study is a case-control study based on New National Cholesterol Education Programme Adult Treatment Panel III which approved the criteria of metabolic syndrome. Forty-eight (48) patients ( of both sexes ) attending the Diabetic Consultant Clinic for follow up and monitoring therapy during the period from January, 2010 till the end of September, 2010; and forty-eight (48) apparently healthy volunteer that were comparable to patients group with respect to age and sex and serve as a control group were included in this study. They were screened for Metabolic Syndrome criteria: namely, high blood pressure, high body mass index, high fasting blood sugar, high triglyceride, low high density lipoprotein; a significant difference was found between patients and controls with respect to blood pressure, body mass index, fasting blood sugar, triglyceride, and high density lipoprotein (P