Correlation between serum uric acid, nitric oxide, ferrtin and HbA1c levels in Type II diabetic patients

Abstract

Mahalaxmi S Petimani, Prabhakar Adake

Objectives: To estimate fasting plasma glucose (FPG), serum ferritin, HbA1c, uric acid and serum nitric oxide levels in type 2 diabetes mellitus (T2DM) subjects and compare the parameters with healthy controls and also to assess the correlation analysis between the biochemical parameters in T2DM patients. Materials and Methods: A case control study is conducted with a total of 56 diagnosed T2DM subjects and 31 healthy controls. FPG, serum ferritin, HbA1c, uric acid and serum nitric oxide levels were measured in all individuals. Results: The mean levels (mean ± SD) of FPG, serum ferritin, HbA1c, serum uric acid and serum nitric oxide in control group were 98.06±7.28, 84.6±36.8, 5.46±0.84, 4.72±1.41 and 39.0±4.7 respectively. Similarly, in T2DM patients mean levels of 179.5±53.2, 457.9±402.2, 9.49±1.90, 8.57±2.38 and 100.9±26.5 were obtained for respective parameters. In T2DM subjects, mean values of serum ferritin, HbA1c, uric acid and serum nitric oxide were found to be significantly increased (p<0.001) when compared to controls. Moreover, Pearson coefficient analysis has shown that serum ferritin has positive correlation with HbA1c and serum nitric oxide in T2DM patients with p <0.05. Conclusion: The present study confirms the oxidative stress and iron over load among T2DM patients and they might be involved in the pathogenesis of T2DM.