Effect of curcumin and angiotensin II receptor antagonist on insulin sensitivity and on inflammation in induced diabetic rats

Abstract

Mohamed A. Nassar, Ossama A. Mansour, Gamil M. Abd-Allah, Adel F. Kholy

Objective: In this study, we aimed to discuss the effect of curcumin and/or irbesartan on diabetic complications in induced diabetic rats. Materials and Methods: Diabetic rats induced by intraperitoneal injection of 45 mg/kg dose of streptozotocin (STZ) in adult rats. Rats were divided into six groups of 10 rats on each. Serum glucose, creatinine, and urea were estimated using a colorimetric method. Serum insulin and serum and kidney homogenate interleukin 6 (IL-6) were measured using enzyme-linked immunosorbent assay technique. While paraffin-embedded kidney and pancreas specimens were performed for histopathological examination. While homeostasis model assessment of insulin resistance (HOMA-IR) was calculated. Results: Curcumin and/or irbesartan reduce the degradation of kidneys and pancreatic tissues as indicated in both histopathology and tissue IL-6. They improve the weight loss and IR. In addition, they lower circulating level of IL-6, serum creatinine, and urea. Diabetic rats received the medications show significantly better insulin and glucose levels as compared to STZ group. Conclusion: Chronic administration of curcumin and/or irbesartan for diabetic rats decreased serum glucose and HOMA-IR and lowered the increased serum levels of pro-inflammatory cytokines. Using such combination could be beneficial in diabetic managements, especially if diabetes accompanied with hypertension.