Evaluation of glycated albumin and microalbuminuria as early risk markers of nephropathy in type 2 diabetes mellitus

Abstract

Suresh Babu Kondaveeti, Ivvala Anand Shaker

Introduction: Since glycated albumin (GA) reflects with short term variations and these glycated protein shows degree of hyperglycemia, the objective of the study is to find GA and microalbuminuria as an early risk markers along with the duration of uncontrolled diabetes mellitus in type 2 diabetic nephropathy. Materials and Methods: The present cross-sectional study included randomly selected uncontrolled type 2 DM [n=75], controlled type 2 DM [n=75] and healthy controls [n=75]. The fasting venous blood was obtained for GA and serum creatinine, while their morning urine sample was obtained for detection of microalbuminuria. Statistical analysis was done using SPSS version 16.0. One-Way ANOVA was performed. All p-values < 0.05 were considered as statistically significant. Results: The mean GA, microalbuminuria and serum creatinine were the highest in uncontrolled DM when compared with controlled DM respectively. Microalbuminuria and GA had a significant correlation with duration of diabetes (p<0.0001). Conclusion: The present study identifies that the risk of microalbuminuria increases with poor glycemic control. Persistent increase in GA and microalbuminuria may be considered as risk markers in diabetic nephropathy. Therefore, regular screening for microalbuminuria and GA estimation can help in clinical management to prevent complications.