Serum uric acid and its relation to adenosine deaminase, lipid profile and oxidative stress in Diabetes Mellitus type 2

Abstract

Shashikala Magadi Dasegowda, Ashok Kumar Jeppu, Kavitha Ashok Kumar, Sushith Sushith

Aim/Background: Serum uric acid is an end product of purine catabolism. The relationship between the serum uric acid adenosine deaminase, lipid profile and oxidative stress in type 2 diabetes mellitus was studied to evaluate its role as one of the risk factor for coronary artery disease. Methods: The serum uric acid level in type 2 diabetes mellitus was compared with controls. The correlation between serum uric acid with adenosine deaminase (ADA), parameters of oxidative stress and serum lipids was also evaluated. Results: We observed serum uric acid level (5.74±0.49) mg/dl is significantly (p<0.001) increased in type 2 diabetes mellitus when compared to controls (4.38±0.41) mg/dl. Increase in serum uric acid level is significantly associated with increase in adenosine deaminase, malondialdehyde (MDA), total antioxidant capacity (TAC), serum triglyceride(TG), total cholesterol (TC) and low density lipoprotein cholesterol (LDL Cholesterol). Further we observed a significant negative correlation between HDL cholesterol and the serum uric acid level. Conclusion: We conclude that increase in serum uric acid level in type 2 diabetes mellitus acts as pro-oxidant. The endothelial dysfunction, proliferation of smooth muscle cells, oxidative stress will facilitate atherogenesis and its progression. A strong association between serum total cholesterol, LDL cholesterol, serum triglyceride, and the inverse relationship between the high density lipoprotein cholesterol and serum uric acid observed in the present study suggests that serum uric acid has a role in coronary artery disease.