Th e study of biochemical parameters showing atherogenic eff ect in Type 2 diabetic nephropathy

Abstract

Sureshbabu Kondaveeti, Anand Shaker Ivvala, Bhuvana Karthikeyan

Aim: Diabetic nephropathy is one of the major complications of diabetes mellitus characterized by frequent microalbuminuria, elevated arterial blood pressure, a persistent decline in glomerular filtration rate and a high risk of cardiovascular morbidity and mortality. Methods: The study comprised of 30 diabetic mellitus (DM) with microalbuminuria patients (Group 3), 30 DM without microalbuminuria patients (Group 2) compared with 30 healthy controls (Group 1). Fasting glucose, post prandial glucose, lipid profile, fructosamine and microalbuminuria were investigated in all the groups. Results: A significant increase in serum fructosamine, fasting and post prandial glucose levels along with increased microalbuminuria observed in Group 3 patients compared to Group 2 and Group 1 patients. Conclusion: Hyperglycemia, increased fructosamine and increased cholesterol, triglycerides with decreased high-density lipoprotein-cholesterol levels indicates the major risk of atherogenicity.