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Fredry Hellen
Department of Pharmacy, University of Rochester, New York, USAPublications
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Research Article
Evaluation of Nicotine Pharmacokinetics among Flavors in Electronic Nicotine Delivery Systems (ENDS): A Parallel, Randomized Study in Two ENDS across Four Flavors
Author(s): Jourhan Lew, Riaz Brette, Eddy Dae*, Elaine Round, Fredry Hellen and Sarah Baxter-Wright
Introduction: The impact of e-liquid flavor on nicotine uptake is an important area of consideration regarding biological uptake of nicotine with conflicting data. This paper reports on Pharmaco Kinetics (PK) of plasma nicotine uptake and a subjective measure of Overall Product Liking (OPL) using four different e-liquid flavors in two commercially available cartridge-based Electronic Nicotine Delivery System (ENDS) systems, Vuse Vibe and Vuse Ciro. Aims and methods: Two single-center, open-label, parallel cohort confinement studies were conducted in 2017. In total, 287 eligible adult cigarette smokers and dual users of ENDS were enrolled and randomized to Vuse Vibe (3% nicotine content by weight) in four flavors (Original (n=36), Mint (n=36), Tropical (n=36), or Nectar (n=36)), or to Vuse Ciro (1.5% nicotine content by weight) in four flavor.. Read More»